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Year 2020

Volume: 5 , Issue: 1

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IP Archives of Cytology and Histopathology Research

Histopathological and immunohistochemical study of lymphnodal biopsies

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Research Article

Author Details : Ramya Potti, Venkata Renuka Inuganti*, Chaitra B, Garima B, Durga Prasad B

Volume : 5, Issue : 1, Year : 2020

Article Page : 70-74

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Introduction: Diseases affecting lymph nodes form a wide range of spectrum, from simple infection to
malignant pathology. A panel of IHC markers is decided based on morphologic differential diagnosis.
Aims and Objectives: To study the incidence of lymph nodal lesions with respect to age and sex and
their different histopathological patterns. To use Immunohistochemistry (IHC) for sub typing of neoplastic
Materials and Methods: This study was done for a period of two and a half years in the Department
o f Pathology, from Jan 2017 to June 2019. All the specimens received were fixed in 10% formalin and
routinely processed and stained with Hematoxylin and Eosin (H&E.)
Results: A total of 230 lymph node biopsies were studied. Age distribution varied from 3 to 83 years
with female preponderance. Non – Neoplastic lesions were common comprising of 120 cases (52%)
while neoplastic lesions were 110 (48%). Among non neoplastic lesions reactive lymphadenitis (23%) was
common followed by tuberculous lymphadenitis (21%). In neoplastic lesions, metastatic diseases (20%)
predominated. IHC was done wherever necessary for subtyping of lymphomas and also to differentiate
lymphoma from carcinoma.
Conclusion: Lymph node biopsy with IHC plays an important role in establishing the cause for
lymphadenopathy and thus aids in therapy.

Keywords: Lymph node, Immunohistochemistry, Non-neoplastic, Neoplastic.

Doi : 10.18231/j.achr.2020.014

How to cite : Potti R, Inuganti V R, Chaitra B, Garima B, Durga Prasad B, Histopathological and immunohistochemical study of lymphnodal biopsies. IP Arch Cytol Histopathol Res 2020;5(1):70-74

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