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Year 2020

Volume: 5 , Issue: 1

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IP Archives of Cytology and Histopathology Research

Primary clear cell adenocarcinoma of the vagina in a young female with uterus didelphys

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Case Report

Author Details : Anshul Singh, Shatakshee Tewari*, Satyam , Kachnar Varma, Vatsala Misra

Volume : 5, Issue : 1, Year : 2020

Article Page : 104-108

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Introduction: Adenocarcinomas of clear cell type are uncommon tumors accounting for 5-10% of all
vaginal tumours which in turn account for approximately 2% of all gynaecologic malignancies. Though
Clear cell Adenocarcinomas arising in the setting of previous Di-Ethyl–Stilbesterol [DES] exposure have
been reported quite often, only few cases of these not associated with DES have been documented.
Amongst non-DES exposed patients, CCAs are said to be sporadic or in association with endometriosis in
women of peri/postmenopausal age or in association with some congenital genitourinary anomalies mostly
affecting young females.
Case Report: A 16 year old female presented with heavy bleeding per vaginum since 2 months. On per
vaginal examination a polypoidal mass was felt on posterior wall of vagina. Ultrasonography revealed
the presence of a uterus didelphys in addition to this mass. Polypectomy was done. On microscopy, a
diagnosis of clear cell adenocarcinoma was made which was confirmed on immunohistochemistry. There
was no history of any DES exposure in the mother.
Conclusion: We present here a case of an adolescent female with uterus didelphys and no DES exposure
who was diagnosed as a case of Vaginal Clear cell Adenocarcinoma. The rarity of this tumour among DESexposed
cases and its presence in non-exposed patients warrants a more thorough search for the underlying

Keywords: Mesonephric carcinoma, Genitourinary malformations, Non diethylstilbestrol, Tumours of adolescent females.

Doi : 10.18231/j.achr.2020.021

How to cite : Singh A , Tewari S, Satyam, Varma K, Misra V, Primary clear cell adenocarcinoma of the vagina in a young female with uterus didelphys. IP Arch Cytol Histopathol Res 2020;5(1):104-108

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