COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Article view: 539

Article download: 202

IP Archives of Cytology and Histopathology Research


Disorders of sex development -A complex puzzle for the doctor and the patient-A rare case report


Full Text PDF Share on Facebook Share on Twitter


Author Details : Kusum Jashnani, Vivek Parameshwar*, Sneha D. Sirodkar

Volume : 3, Issue : 4, Year : 2018

Article Page : 227-230


Suggest article by email

Abstract

Disorders of Sex Development (DSD) are referred to a group of disorders in which at least two out of gonadal sex, genetic sex, phenotypic sex and genital tract sex show discordance between them. Among the three main categories of DSD, 46XY DSD is a rarer type which we encountered in our case. A 14 year old female presented with abdominal pain and lump since 10 days. On clinical examination she had external sexual characters of a female. Karyotyping revealed a 46XY type. Intra-operatively, there was a normal uterus with a tumor mass in the location of the right gonad which was removed, along with a biopsy taken from the contralateral gonad, both intra-abdominal in location. Histopathologic examination of the tumor mass revealed a malignant mixed germ cell tumour (GCT) comprising of dysgerminoma and yolk sac tumour and the contralateral gonad was found to be testis, with evidence of intratubular germ cell neoplasm unclassified (IGCNU). Patient underwent 4 cycles of chemotherapy after the histopathologic diagnosis but was later lost to follow-up. The relative ambiguity of these disorders with their propensity to develop into type II GCTs makes these cases unique, perplexing and of utmost importance.

Keywords: 46XY DSD, Mixed GCT, IGCNU.

Doi : 10.18231/2456-9267.2018.0046

How to cite : Jashnani K, Parameshwar V, Sirodkar S D, Disorders of sex development -A complex puzzle for the doctor and the patient-A rare case report. IP Arch Cytol Histopathol Res 2018;3(4):227-230

Copyright © 2018 by author(s) and IP Arch Cytol Histopathol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)