COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Print ISSN:-2581-5725

Online ISSN:-2456-9267


Current Issue

Year 2020

Volume: 5 , Issue: 1

Article Access statistics

Viewed: 472

Emailed: 0

PDF Downloaded: 154

IP Archives of Cytology and Histopathology Research

Histopathological study of placental changes associated with pre-eclampsia and eclampsia in a tertiary care centre of Puducherry

Full Text PDF Share on Facebook Share on Twitter

Author Details : Shanmugasam K*, Anandraj Vaithy, Rupal Samal, Uma Devi K R, Sowmya

Volume : 4, Issue : 1, Year : 2019

Article Page : 57-60

Suggest article by email


Introduction: Foetal development mainly depends on normal placental development. Mother, Placenta and Foetus are related to each other during the course of the pregnancy. Pregnancy induced hypertension shows considerable changes in the histopathology of placenta. Therefore the main aim of the present study is to evaluate the morphological changes of placenta in case of Pregnancy Induced Hypertension (PIH) and to correlate the findings with severity of toxaemia of pregnancy.
Materials and Methods: The present study includes 61cases of placenta out of which 51 are in the study group and 10 cases are in the control group. Our study was descriptive study conducted in the Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidhyapeeth University, Puducherry during the period of July 2015-June 2018. The study group were further divided into four categories. All the placenta are grossed according to the institute protocol and the slides were examined for various morphological changes and correlated with the severity of pre-eclampsia and eclampsia. Descriptive statistics were used to evaluate the results.
Results: The most prominent lesion seen in the toxaemia of pregnancy were villous cytotrophoblastic proliferation and villous fibrinoid necrosis which accounts to 78% and 75% respectively. Villous stromal fibrosis constitutes 71% of the study group cases. Increased villous vascularity was seen in 39% of the placenta of toxaemia of pregnancy. 69% of the cases shows villous basement membrane thickening in the study group placenta.
Conclusion: Our study helps in evaluating the various morphological changes in placenta in the hypertensive disorder of pregnancy. This study helps in anticipating the occurrence of changes in the subsequent pregnancy induced hypertension cases.

Keywords: Pregnancy, Eclampsia, Cytotrophoblastic cell proliferation, Fibrinoid necrosis.

Doi : 10.18231/2456-9267.2019.0009

How to cite : Shanmugasam K, Vaithy A, Samal R, Uma Devi K R, Sowmya, Histopathological study of placental changes associated with pre-eclampsia and eclampsia in a tertiary care centre of Puducherry. IP Arch Cytol Histopathol Res 2019;4(1):57-60

Copyright © 2019 by author(s) and IP Arch Cytol Histopathol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (