IP Archives of Cytology and Histopathology Research

Coats' Disease of the Retina: A rare entity that merits consideration in diagnosis: A mini review

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Author Details: Amal Abd El hafez

Volume : 2

Issue : 2

Online ISSN : 2456-9267

Print ISSN : 2581-5725

Article First Page : 55

Article End Page : 58


Coats’ disease is an idiopathic retinal vascular disorder with particular affection of young male patients. Different theories have been proposed to explain the pathophysiology of Coats' disease including genetic mutation, pericyte loss, breakdown of the endothelial blood-retinal barrier and hypercholesterolemia. The disease presents clinically with strabismus and leukocoria that should be differentiated from retinoblastoma and other clinical conditions with the same features. It is crucial for the pathologist to be familiar with the characteristic histopathological features of Coats' disease including telangiectatic retinal vessels, exudative retinal detachment, and disorganization of ocular structure with deposition of lipid material eliciting foreign-body granuloma. Ophthalmoscopy is often sufficient to make the diagnosis of Coats’ disease; however, other diagnostic modalities may be necessary. The management of Coats’ disease is dependent on its clinical stage.

Doi No:-10.18231