COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-708X

Online ISSN:-2278-3784

CODEN : IDJSB7

Current Issue

Year 2020

Volume: 8 , Issue: 1

Article Access statistics

Viewed: 669

Emailed: 0

PDF Downloaded: 177

International Dental Journal of Student Research


Expression of toll like receptor 4 and cluster of differentiation 14 in chronic periodontitis patients- an immunohistochemical study


Full Text PDF Share on Facebook Share on Twitter


Author Details : Raikar Anita S, Nayak Aarati R, Kotrashetti Vijaylaxmi S, Kunal Keshaw, Sumedha Shree

Volume : 5, Issue : 3, Year : 2017

Article Page : 73-79


Suggest article by email

Abstract

Introduction: Toll like receptors along with their co receptors contribute an essential task in immune and destruction mechanism. The aim of the present study was expression of Toll like receptor 4 and Cluster of differentiation 14 in healthy group and chronic periodontitis group.
Materials and Method: Forty gingival biopsies were harvested of which10 were of healthy subjects and 30 from chronic periodontitis based on clinical records. All specimens were fixed, processed and stained by haematoxylin and eosin to histologically classify periodontitis. Later the sections were stained immunohistochemically using primary antibody for toll like receptor 4 and cluster of differentiation 14 respectively.
Results: The positive expression of both Toll Like Receptor 4 and Cluster of Differentiation14 was defined as light or dark brown granules in the cytoplasm of the cell. Expression was higher in zone1 followed by zone 2 and zone 3 in chronic periodontitis.
Conclusion: Toll Like Receptors act as a two-edged sword, not only maintaining periodontal health but also contributing to periodontal tissue destruction.

Keywords:
TLR4, CD14, immunohistochemistry, Chronic periodontitis, Innate immunity

How to cite : Raikar Anita S, Nayak Aarati R, Kotrashetti Vijaylaxmi S, Keshaw K, Shree S, Expression of toll like receptor 4 and cluster of differentiation 14 in chronic periodontitis patients- an immunohistochemical study. Int Dent J Stud Res 2017;5(3):73-79

Copyright © 2017 by author(s) and Int Dent J Stud Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)