COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article Access statistics

Viewed: 281

Emailed: 0

PDF Downloaded: 97

IP International Journal of Aesthetic and Health Rejuvenation

Insulin resistance related to Vitamin D deficiency in gestational diabetes mellitus

Full Text PDF Share on Facebook Share on Twitter

Research Article

Author Details : Shaik Mahmood*

Volume : 2, Issue : 1, Year : 2019

Article Page : 11-13

Suggest article by email


Introduction: Beta cells in the pancreas secrete insulin, C-Peptide. C-Peptide is marked as an indicator of insulin secretion. Dysregulation of insulin - mediated metabolic pathways has emerged as an underlying malfunction through which vitamin D deficiency in gestational diabetes may be linked. Vitamin D deficiency is also associated with resistance and pancreatic beta cell dysfunction. Vitamin D activity increases insulin release and insulin secretion from pancreatic islet bet cells. C – Peptide hormone is an indicator of insulin secretion and is a connecting peptide. It is removed when insulin is released and secreted in the first and second phases of insulin secretion. Optimal vitamin D homeostasis may be essential for both insulin secretion and action, two fundamental features in the pathogenesis of insulin resistance and diabetes. The present study was designed to demonstrate the relationship between 25 – Hydroxyl Vitamin D (25 (OH)D) Levels and Insulin Resistance (IR) in normal pregnancy and Gestational Diabetes Mellitus (GDM). The study included 150 pregnant women classified into two main groups normal present (n=100) and GDM (n=50). Further classification for each group was carried out based on 25(OH)D, Fasting Blood Glucose (FBG), Fasting Insulin (FI) C – Peptide and Insulin Resistance (IR) markers were calculated including Glucose / Insulin ration (G/I). Results indicated significantly increased FBG, FI, C-Peptide compared to control group, no significant correlations were obtained between 25(OH)D and any tested parameters, however, in GDM 25(OH)D showed significant corrections with FBG. Thus this indicating that 25(OH)D way be associated with elevated IR that accompanying GDM.

Keywords: Gestational diabetes mellitus, Vitamin D, Insulin resistance, C – Peptide.

How to cite : Mahmood S, Insulin resistance related to Vitamin D deficiency in gestational diabetes mellitus. Int J Aesthet Health Rejuvenation 2019;2(1):11-13

Copyright © 2019 by author(s) and Int J Aesthet Health Rejuvenation. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (