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Indian Journal of Clinical Anaesthesia

Intranasal midazolam: Sedation for radiological procedures

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Research Article

Author Details : Daxa Hiren Oza*, Vaibhavi Patel, Priya Pathak, Rahul C Manek, Miunalini G Patel

Volume : 6, Issue : 4, Year : 2019

Article Page : 493-496

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Context: Preoperative stress, anxiety and lack of cooperative ability of paediatric patients need sedation
for radiological procedure.
Aims: The purpose of study is to compare and evaluate efficiency and safety of two doses of intranasal
Settings and Design: This is a prospective Randomized controlled study of interventional type of study.
Methods and Material: Sixty patient of age 1 to 4 years, ASA 1 and ASA2 undergoing radiological
procedure were randomly divided into two groups. Group A received 0.3 mg/kg and Group B received
0.5 mg/kg of intranasal spray of midazolam. Sedation score, haemodynamic variations, ease of separation,
Venepunture response and side effect were studied.
Statistical analysis used: Data analysis was performed using SPSS for Windows, version 20.0(SPSS Inc.,
Chicago, IL)
Results: Higher sedation score achieved earlier with 0.5mg/kg dose, Parenteral separation and IV line
insertion was more easier with 0.5 mg/kg dose but recovery slight delay compare to 0.3 mg/kg dose after
20 min of procedure completion but there was no much prolongation of recovery time, at 30 min of all
patient discharged in both groups.
Conclusions: High Sedation score, parentral separation and response to IV line was earlier and easier with
0.5 mg/kg dose.
Key Messages: Intranasal Midazolam is safe and effective as sedative in paediatric radiological procedure.

Keywords: Intranasal, Midazolam, Radiological procedure.

Doi : 10.18231/j.ijca.2019.096

How to cite : Oza D H, Patel V, Pathak P, Manek R C, Patel M G, Intranasal midazolam: Sedation for radiological procedures. Indian J Clin Anaesth 2019;6(4):493-496

Copyright © 2019 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (