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Indian Journal of Clinical Anaesthesia

Comparasion of intravenous Nalbuphine versus intravenous Paracetamol for postoperative analgesia in patients undergoing surgeries under general anaesthesia

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Author Details : Rashmi H D, Hanumanthappa V Airani*

Volume : 6, Issue : 4, Year : 2019

Article Page : 553-558

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Introduction: Postoperative pain is the most annoying symptom that every patient will complain after the
surgery. Relief of this pain greatly improves the patient satisfaction, compliance and recovery. Opioids and
NSAIDs are the most commonly used analgesics in the postoperative period. The need for the study was to
compare the efficacy of intravenous Nalbuphine over intravenous Paracetamol in the postoperative period.
Materials and Methods: 60 patients who underwent elective surgeries under general anaesthesia were
selected for the study. 30 patients in Group P received Inj. Paracetamol 15 mg/kg body wt. and 30 patients
in Group N received Inj. Nalbuphine-0.15 mg/kg body wt over 15 min. Both the groups received the study
drug half an hour before the completion of surgery.
Postoperative pain scores were measured using VAS pain score and postoperative haemodynamic
parameters were measured at regular intervals. The time for the first dose of rescue analgesia was noted.
Side effects like sedation, nausea, vomiting, pruritus were assessed at regular intervals postoperatively until
10 hours.
Results: Demographic profile were comparable between the groups. Both Nalbuphine and Paracetamol
can be effectively used for treating postoperative pain. But Nalbuphine is used as safer alternative since
the duration of analgesia is longer in Nalbuphine group when compared to Paracetamol group without
significant side effects. Haemodynamic stability was maintained in both the groups.
Conclusions: IV Nalbuphine is a better cost effective alternative to IV Paracetamol in alleviating the
postoperative pain with prolonged duration of analgesia and hemodynamic stability without significant
side effects.

Keywords: Intravenous Nalbhupine, Paracetamol postoperative analgesia, VAS score, Haemodynamic variables sedation.

Doi : 10.18231/j.ijca.2019.108

How to cite : Rashmi H D, Airani H V, Comparasion of intravenous Nalbuphine versus intravenous Paracetamol for postoperative analgesia in patients undergoing surgeries under general anaesthesia. Indian J Clin Anaesth 2019;6(4):553-558

Copyright © 2019 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (