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CODEN : IJCACT

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Indian Journal of Clinical Anaesthesia


To compare the efficacy of dexmedetomidine and esmolol in attenuation of pressor response to laryngoscopy and intubation in patients undergoing general anaesthesia for elective laparoscopic cholecystectomy


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Research Article

Author Details : Saurabh Varshney, Vaibhav Shahi*, Madhu Bhardwaj

Volume : 6, Issue : 4, Year : 2019

Article Page : 576-580


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Abstract

Aims: Assessment of the degree of attenuation of pressor response to tracheal manipulation, with Esmolol
and Dexmedetomidine as premedication, in patients posted for elective laparoscopic cholecystectomy.
Settings and Design: The current randomised prospective study was designed and sixty patients of
American Society of Anaesthesiologist class I and II undergoing laparoscopic cholecystectomy were
included in the study.
Methods and Materials: Sixty patients were randomised into two groups, Group E and Group D. Patients
of group E (n=30) received Inj. Esmolol (0.50 mg/kg) in 10 ml normal saline two minutes before intubation
and patients of group D (n = 30) received Inj. Dexmedetomidine (0.5mg/kg) in 10 ml normal saline over
10 minutes prior to intubation. In both the groups, at baseline and at various time intervals after study drug
administration, hemodynamic parameters were recorded.
Statistical analysis: SPSS software version 15.0 is used for statistical analysis. The values were
represented as Mean SD. Student’s t-test was used for analysis of various parameters.
Results: The demographic data and initial baseline hemodynamics were statistically similar. The
sympathetic response to tracheal manipulation was significantly attenuated (p<0> but dexmedetomidine blunts the pressor response more effectively.
Conclusion: Among dexmedetomidine and esmolol, dexmedetomidine seem to be a promising drug to
control the pressor response to tracheal manipulation.

Keywords: Esmolol, Laparoscopic cholecystectomy, Dexmedetomidine.

Doi : 10.18231/j.ijca.2019.112

How to cite : Varshney S, Shahi V, Bhardwaj M , To compare the efficacy of dexmedetomidine and esmolol in attenuation of pressor response to laryngoscopy and intubation in patients undergoing general anaesthesia for elective laparoscopic cholecystectomy. Indian J Clin Anaesth 2019;6(4):576-580

Copyright © 2019 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)