COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-4781

Online ISSN:-2394-4994

CODEN : IJCACT

Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 210

Emailed: 0

PDF Downloaded: 129

Indian Journal of Clinical Anaesthesia


A comparative clinical study between dexmedetomidine and nitroglycerine for controlled hypotensive anaesthesia in spine surgeries


Full Text PDF Share on Facebook Share on Twitter


Research Article

Author Details : Meena Paul. P, V Y Srinivas*, Jyothsna Gopinathank N K, Harikrishnan K.V

Volume : 6, Issue : 4, Year : 2019

Article Page : 581-586


Suggest article by email

Abstract

Background and Objective: To reduces the intraoperative blood loss and to provide better visibility of
the surgical field controlled hypotension is used. Aim of this study is to compare dexmedetomidine and
nitroglycerine as hypotensive agents for inducing controlled hypotension in patients undergoing elective
spine surgeries.
Materials and Methods: 60 ASA class I or II adult patients undergoing elective spine surgeries were
randomly alloca ted into 2 groups of 30 participant in each group DX and group NG . Group DX received
dexmeditomidine bolus 1 microgram/kg over 10 minutes before induction and intraoperative infusion of
0.2 - 0.7 microgram per kg per hour, while group NG received nitroglycerine intraoperative infusion at
0.5 to 10 microgram/kg/ min titrated to a mean arterial pressure (MAP) of 70 - 75 mmHg. In both groups
the surgical field quality assessed using Fromme - Boezaart grading. Hemodynamic variable and adverse
events were noted. Post operative sedation was also assessed using Ramsay sedation score.
Results: The mean heart rate was significantly lower in group DX compared to group NG throughout the
procedure. (p<0> group NG after induction, after intubation, end of surgery, after extubation, and post operatively (p<0> but average intraoperative values were comparable in both groups. Significantly better Fromme - BoezaarT
surgical field score was noted in group DX compared to group NG during the intraoperative period.
Conclusion: Controlled hypotension using dexmeditomidine as bolus dose 1 microgram per kg intravenous
over 10 minutes prior to induction followed by continous intravenous infusion at 0.2 - 0.7 microgram per kg
per hour, provided more stable hemodynamics and better surgical field quality compared to nitroglycerine
intraoperative infusion at 0.5 to 10 microgram/kg/min.

Keywords: Anaesthesia, Controlled hypotension, Spine surgeries, Dexmedetomidine, Nitroglycerine.

Doi : 10.18231/j.ijca.2019.113

How to cite : Meena Paul. P, Srinivas V Y, Jyothsna Gopinathank N K, K.v H, A comparative clinical study between dexmedetomidine and nitroglycerine for controlled hypotensive anaesthesia in spine surgeries. Indian J Clin Anaesth 2019;6(4):581-586

Copyright © 2019 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)