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Indian Journal of Clinical Anaesthesia


Comparative study of palonosetron and ondansetron in prevention of post operative nausea and vomiting after laparoscopic gynaecological surgeries


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Research Article

Author Details : Ankita Choudhary*, Vinod Parashar

Volume : 7, Issue : 1, Year : 2020

Article Page : 59-63


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Abstract

Introduction: Post operative nausea and vomiting (PONV) is a common complication after general
anaesthesia, specially post laparoscopic surgeries. This study compared efficacy of palonosetron with
ondansetron for prevention and management of PONV in patients undergoing laparoscopic gynaecological
surgeries.
Materials and Methods: 100 patients, undergoing laparoscopic gynaecological surgery were randomly
divided in 2 groups of 50 each. They received either ondansetron(4mg IV) or palonosetron (0.075mg IV)
before induction of general anaesthesia. They were monitored post operatively till 72 hours for episodes of
nausea, vomiting, overall PONV and adverse effects.
Result: The incidence of overall PONV was significantly less in patients who received palonosetron as
compared those who received ondansetron. Also, ondansetron group demonstrated higher use of rescue
anti-emetic drug as compared with palonosetron group. No significant difference was found in incidence
of adverse effects in both groups.
Conclusion: Palonosetron, having longer duration of action, is more effective in treating long term PONV
compared to ondansetron in patients undergoing laparoscopic gynaecological surgeries under general
anesthesia.

Keywords: Palonosetron, Ondansetron, Post operative nausea vomiting, Laparoscopic gynaecological surgeries, Anti-emetic drugs.

Doi : 10.18231/j.ijca.2020.011

How to cite : Choudhary A, Parashar V , Comparative study of palonosetron and ondansetron in prevention of post operative nausea and vomiting after laparoscopic gynaecological surgeries. Indian J Clin Anaesth 2020;7(1):59-63

Copyright © 2020 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)