COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 76

Article download: 40

Indian Journal of Clinical Anaesthesia

Sedative effect of propofol and midazolam in surgery under spinal anaesthesia: A comparative study

Full Text PDF Share on Facebook Share on Twitter

Research Article

Author Details : Jalpen N Patel, Jyotsna F Maliwad*, Purvi J Mehta, Raman D Damor, Kalpita S Shringarpure

Volume : 7, Issue : 1, Year : 2020

Article Page : 187-191

Suggest article by email


Introduction: Intravenous medications are invariably required to allay anxiety related to surgical
procedures, in patients undergoing surgery under regional anesthesia. A thorough pre anaesthetic check
up and details of the surgical procedure planned are necessary before administration of sedative agents to
attain desirable levels of sedation and avoid unwanted adverse events.
Objective: To observe, record and analyse sedative effect of intravenous Propofol and Midazolam in lower
extremities and lower abdominal surgery scheduled under regional anesthesia techniques.
Materials and Methods: A single blinded comparative study conducted in tertiary care hospital of Gujarat.
Sixty patients with no organic pathology & a moderate but definite systemic disturbance categorized into
two groups labeled as propofol group (n=30) and Midazolam group (n=30) of either gender and shortlisted
for surgery using subarachnoid block. Observer’s Assessment of Alertness/Sedation Scale (OAA/S Scale)
and Ramsay sedation scale was used to assess effective sedation.
Results: Basic patients characteristics, Mean age (SD) was 31.57 + 10.57 years in category I (P group) and
35.33 + 9.98 years in category II (M group) was comparable between the groups. In category I 16(53.3%)
patients reached targeted sedation level in < 60> seconds to achieved the same level of sedation (p<0> Conclusion: Propofol gives rapid onset of sedation and faster recovery, while midazolam provides more
hemodynamic stability in regional anesthesia.

Keywords: Sedative effect, Subarachnoid block, Anxiety.

Doi : 10.18231/j.ijca.2020.033

How to cite : Patel J N, Maliwad J F, Mehta P J, Damor R D, Shringarpure K S, Sedative effect of propofol and midazolam in surgery under spinal anaesthesia: A comparative study. Indian J Clin Anaesth 2020;7(1):187-191

Copyright © 2020 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (