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CODEN : IJCACT

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Year 2020

Volume: 7 , Issue: 2

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Indian Journal of Clinical Anaesthesia


Evaluation of the efficacy of single dose of 0.6mcg/kg of iv dexmedetomidine for the attenuation of sympathoadrenal response to extubation


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Research Article

Author Details : Sindhu S*, V Y Srinivas

Volume : 7, Issue : 2, Year : 2020

Article Page : 344-347


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Abstract

Background: General anaesthesia with endotracheal intubation is the definite way of securement
of airway. Tracheal extubation is associated with increased sympathoadrenal response which leads
to deleterious consequences in susceptible patients. This study aims to evaluate the efficacy of
dexmedetomidine 0.6mcg/kg iv in the suppression of sympathoadrenal response to tracheal extubation.
Materials and Methods: Sixty participants aged between 18-55yrs belonging to ASA 1 or 2 were
randomly allocated into 2 groups. Group Dxd received injection Dexmedetomidine 0.6mcg/kg iv and Group
Cl received normal saline. Heart rate, systolic and diastolic blood pressure were recorded at baseline, 2, 5,
8 minutes after drug infusion, at extubation and 1,3,5,8,10 and 15 minutes post extubation.
Results: Group Dxd showed lower heart rate, systolic and diastolic blood pressure at extubation, and till
15minutes postextubation compared to Group Cl.
Conclusion: Dexmedetomidine 0.6mcg/kg iv effectively attenuates the sympathoadrenal response to
tracheal extubation.

Keywords: Dexmedetomidine, Extubation, Sympathadrenal response.

Doi : 10.18231/j.ijca.2020.062

How to cite : Sindhu S, Srinivas V Y, Evaluation of the efficacy of single dose of 0.6mcg/kg of iv dexmedetomidine for the attenuation of sympathoadrenal response to extubation. Indian J Clin Anaesth 2020;7(2):344-347

Copyright © 2020 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)