COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Print ISSN:-2394-4781

Online ISSN:-2394-4994


Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 685

Emailed: 0

PDF Downloaded: 174

Indian Journal of Clinical Anaesthesia

The Effect of Clonidine on Hemodynamics, Recovery and Post-Operative Pain in Laparoscopic Gynaecological Surgeries: A Comparative Study Involving Two Routes of Administration

Full Text PDF Share on Facebook Share on Twitter

Author Details : Pushpa Rani, K.Vijayanand M

Volume : 2, Issue : 4, Year : 2015

Article Page : 240-245

Suggest article by email


Background: Laparoscopy requires creation of a pneumoperitoneum which produces a significant rise in heart rate, mean arterial pressure, reduction in venous return and systemic vascular resistance. Various pharmacologic agents are used to control hemodynamic changes associated with pneumoperitoneum.
Aim: To compare the effects of Clonidine administered intravenously (group IV) and intraperitoneally (group IP) on hemodynamics,recovery and post-operative pain in patients undergoing elective laparoscopic gynaecological surgeries.
Study design: Randomized controlled trial.
Methodology: Sixty patients undergoing elective laparoscopic gynaecological surgeries were selected. General anaesthesia was administrered in all cases.After inserting ports Group IV: received Clonidine 1µg/kg i.v along with Ropivacaine 0.25% 20cc intraperitoneally using a ryles tube introduced and directed towards hepatophrenic recess Group IP: received Clonidine 1µg/kg along with Ropivacaine 0.25% 20cc.intraperitoneally Vitals weremonitored every 30min during the procedure. Postoperatively oxygen saturation,heart rate, and blood pressure weremonitored.Aldrete recovery scoring system was used to assessreadiness for discharge. When the score was>8, and pain was monitored using VAS scoring in lying and sitting posture next 12hours.
Statistical Analysis: Continous data was analysed using student t-test while categorical data was analysed using fisher’s exact test and chi square test.
Results: Intravenous Clonidine significantly reduced the MAP (group IP: 80.5±6.7,group IV: 67.44±5.6) during intraoperative period while intraperitoneal group showed reduced MAP in postoperative period (group IP: 75.98±7.35, group IV: 83.36±17.05). Heart rate both during intraoperativeperiod (group IP: 63.2±6.35, group IV: 77.6±9.35) and postoperative period (group IP: 75.6±7.35, group IV: 83.36±17.05) showed significant decrease in intraperitoeal group. Intraperitoneal Clonidine showed better hemodynamic control by maintaining heart rate and MAP postoperatively  and better recovery  profile in the form of VAS Scoring(2.0±0.618 p value <0.05)  and time to request first rescue analgesia(6.567±0.9 p value <0.05).
Conclusion: Clonidine when added to ropivacaine (0.25%) intraperitoneally provide better hemodynamic control and prolonged analgesia with less side effects than intravenous clonidine.

Keywords: Clonidine, Ropivacaine, Intravenous, Intraperitoneal, laparoscopic surgery


How to cite : Rani P, K.vijayanand M, The Effect of Clonidine on Hemodynamics, Recovery and Post-Operative Pain in Laparoscopic Gynaecological Surgeries: A Comparative Study Involving Two Routes of Administration. Indian J Clin Anaesth 2015;2(4):240-245

Copyright © 2015 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (