COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-4781

Online ISSN:-2394-4994

CODEN : IJCACT

Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 615

Emailed: 0

PDF Downloaded: 164

Indian Journal of Clinical Anaesthesia


Efficacy of dexmedetomidine premedication on attenuation of intraocular pressure changes after succinylcholine and endotracheal intubation


Full Text PDF Share on Facebook Share on Twitter


Author Details : Sreenivas Reddy M., Pradeep Hosagoudar, Giridhar J. B., Y. V. Murali, K. V. Srinivasan

Volume : 5, Issue : 1, Year : 2018

Article Page : 134-140


Suggest article by email

Abstract

Introduction: Succinylcholine, is one of the most commonly used muscle relaxant for rapid sequence airway management. It increases the Intraocular pressure (IOP) which is deleterious in open globe injuries. We studied the effects of Inj. dexmedetomidine, a highly selective α2-adrenoceptor agonist, on IOP and hemodynamic responses to succinylcholine and tracheal intubation.
Materials and Methods: Sixty ASA I–II patients, scheduled for elective non-ophthalmic surgeries requiring general anesthesia were randomly premedicated by intravenous Inj. dexmedetomidine 0.4 µg/kg (Group-D) or saline (Group-S) (30 patients each group). Heart rate (HR), mean arterial pressure (MAP), and IOP (using Schiotz tonometer) were measured 10 minutes before and after the premedication, 30 seconds after succinylcholine and at 1, 5 and 10 minutes after intubation.
Results: Ten minutes after Inj. dexmedetomidine administration, there was marked decrease in IOP. After intubation there was a rise in IOP, however it remained below baseline IOP (p=0.315) and remained low at 10th minute after intubation (p<0.001) which was statistically significant. In the control group, there was a significant rise in IOP following Inj. succinylcholine and intubation which remained above baseline IOP even at 10th minute after intubation. HR, Systolic and diastolic blood pressure, and MAP markedly increased at 1 minute following intubation in the control group whereas in dexmedetomidine group, they remained below baseline (p<0.001).
Conclusions: Intravenous dexmedetomidine at a dose of 0.4 μg/kg can be used for attenuation of rise in IOP associated with succinylcholine and tracheal intubation in patients with open globe injuries.

Keywords:  Dexmedetomidine, Eye, Intraocular pressure, Rapid sequence intubation,
Succinylcholine.

Doi : 10.18231/2394-4994.2018.0023

How to cite : Sreenivas Reddy M., Hosagoudar P, Giridhar J. B., Murali Y V, Srinivasan K V, Efficacy of dexmedetomidine premedication on attenuation of intraocular pressure changes after succinylcholine and endotracheal intubation. Indian J Clin Anaesth 2018;5(1):134-140

Copyright © 2018 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)