COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Print ISSN:-2394-4781

Online ISSN:-2394-4994


Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 508

Emailed: 0

PDF Downloaded: 234

Indian Journal of Clinical Anaesthesia

Attenuation of pressor response to laryngoscopy and intubation: Dexmedetomidine Vs. fentanyl premedication

Full Text PDF Share on Facebook Share on Twitter

Author Details : Lalit Kumar Raiger, Gokulakrishnan L, Madhan Chandramohan, Apoorva Aseri, Ravindra Kumar Gehlot*

Volume : 5, Issue : 4, Year : 2018

Article Page : 486-490

Suggest article by email


Introduction: The pressor response during laryngoscopy and intubation is part of a huge spectrum of stress response, results from the increase in sympathetic and sympatho-adrenal activity. The present study was planned to observe the attenuation of pressor response during laryngoscopy and intubation with dexmedetomidine and fentanyl; also to compare the effectiveness between these two drugs.
Materials and Methods: In this study we include 128 patients, of ASA grade I- II, aged 18- 65yrs, of either gender, scheduled for elective surgery under general anaesthesia. Groups: Group D – Dexmedetomidine (0.6µg/kg) and Group F – Fentanyl (2µg/kg), these drugs diluted with NS to make 10 ml, given I.V. slow over 10 min. Vital parameters (HR, SBP, DBP and MBP) were recorded as baseline, then at 10 minutes after pre-medication and then at 1,2,3,5,7 and 10 minutes after endotracheal intubation.
Results: There was significant increase in heart rate, systolic blood pressure and diastolic blood pressure during laryngoscopy and intubation in group F as compared to group D (p<0>
Conclusion: Dexmedetomidine (0.6mcg/kg) is superior to fentanyl (2mcg/kg) in the attenuation of the pressor response and that the ideal time for its administration should be about 10 minutes before a laryngoscopy and intubation.

Keywords: Dexmedetomidine, Fentanyl, Intubation, Laryngoscopy, Pressor response.

Doi : 10.18231/2394-4994.2018.0093

How to cite : Raiger L K, Gokulakrishnan L, Chandramohan M, Aseri A, Gehlot R K, Attenuation of pressor response to laryngoscopy and intubation: Dexmedetomidine Vs. fentanyl premedication. Indian J Clin Anaesth 2018;5(4):486-490

Copyright © 2018 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (