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Indian Journal of Clinical Anaesthesia

Efficacy of flupirtine maleate as pre-emptive analgesic

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Research Article

Author Details : Lakshmi Priya, Dinesh Govindarao*, Vinay M S

Volume : 6, Issue : 3, Year : 2020

Article Page : 391-394

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Introduction and Aim: Post-surgical pain treated with NSAIDs and opioids is associated with many adverse effects and poor patient satisfaction. Our aim was to study the effect of oral Flupirtine (200mg), as a pre-emptive analgesic in maxillo-facial surgeries.
Materials and Methods: A total of 60 patients between 18-60 years, ASA I and II, scheduled for maxillo-facial surgeries were randomised to receive orally Flupirtine maleate capsule (200mg) or Vitamin B complex capsule 2 hrs prior to surgery under general anaesthesia. The severity grading of post operative pain and time taken for first analgesic dose requirement in the post operative period was measured using Visual Analogue Score (VAS) as the primary outcome. Sedation and adverse effects of Flupirtine, if any were studied as the secondary outcome.
Results: Significant delay in demand for first postoperative analgesic dose was observed in the Flupirtine group. After the first four hours of postoperative period, we did not observe any difference in the analgesic demand between the two study groups. There was no significant sedation or adverse effects in the Flupirtine group. In addition, it was observed that hemodynamic response to intubation was significantly attenuated in the Flupirtine group.
Conclusion: Oral Flupirtine maleate is a good pre-emptive analgesic devoid of any side-effects in maxillo-facial surgeries with significant attenuation of intubation response.

Keywords:  Flupirtine maleate, Maxillo-facial surgeries, Pre-emptive analgesia, Intubation response.

Doi : 10.18231/j.ijca.2019.075

How to cite : Priya L, Govindarao D , Vinay M S, Efficacy of flupirtine maleate as pre-emptive analgesic. Indian J Clin Anaesth 2020;6(3):391-394

Copyright © 2020 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (