COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Article view: 191

Article download: 109

Indian Journal of Clinical Anaesthesia


To assess the effect of oral melatonin premedication on propofol requirement for induction in entropy guided general anaesthesia- A randomised double blind study


Full Text PDF Share on Facebook Share on Twitter


Research Article

Author Details : Nethra S.S, Ranjitha Gangadharaiah*, Shubha , Sudheesh K, Devika Rani

Volume : 6, Issue : 3, Year : 2019

Article Page : 410-414


Suggest article by email

Abstract

Introduction: Premedication plays an important role in providing anxiolysis prior to surgery, reduce the intraoperative requirement of intravenous anesthetics and manage perioperative pain. Melatonin premedication has been shown to allay pre-operative anxiety, produce postoperative sedation and reduce analgesic requirement. This study aims to assess the effect of oral melatonin premedication on propofol requirement for induction of anaesthesia.
Materials and Methods: A randomized double blind study was performed on 70 patients of American Society of Anaesthesiologists (ASA) I and II status after obtaining ethical committee clearance. Patients received 3 mg oral melatonin (group M) or placebo (group C) as premedication 60 min prior to surgery (n= 35 in each group). The requirement of propofol for induction was noted using entropy. Patients were assessed for preoperative anxiety using Hamilton anxiety rating scale (HAM) and peri-operative sedation using Ramsay sedation scale (RSS).
Results: The demographic variables were comparable between the 2 groups. There was significant difference between the mean propofol dose requirements for induction in group M and C i.e., 0.96 ± 0.1mg/kg and 2 ± 0.26 mg/kg respectively, with p < 0>
Conclusion: Oral melatonin premedication reduces the induction dose of propofol.

Keywords: Melatonin, Anxiety, Sedation, Propofol consumption.

Doi : 10.18231/j.ijca.2019.079

How to cite : S.s N, Gangadharaiah R, Shubha, Sudheesh K, Rani D, To assess the effect of oral melatonin premedication on propofol requirement for induction in entropy guided general anaesthesia- A randomised double blind study. Indian J Clin Anaesth 2019;6(3):410-414

Copyright © 2019 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)