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Indian Journal of Clinical Anaesthesia


Comparison between the hemodynamic stability of dexmedtomidine and clonidine infusions among patients undergoing laproscopic cholecystectomy- A randomized controlled trial


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Research Article

Author Details : T Rajaprabu*, Vijaya Kumar

Volume : 6, Issue : 3, Year : 2019

Article Page : 437-440


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Abstract

Introduction: The anesthesiologist’s traditional approach to anesthesia for laproscopic cholecystectomy is to ensure that the patient is hemodynamically stable during the entire procedure. Hemodynamic instability is very common during pneumoperitoneum particularly after CO2 insufflations.
Aim: To compare the efficacy between dexmedetomidine and clonidine on hemodynamic stability among patients undergoing laproscopic cholecystectomy.
Materials and Methods: A double blinded randomized controlled trial was conducted by the department of anesthesiology of KLES Dr Prabakhar Kore hospital and research centre for a period of 6 months. Patients undergoing laproscopic cholecystectomy under general anesthesia were included as our study subjects. The entire study subjects were randomized into three groups of 20 each, with one group taken as placebo group and the other two were the study groups with patients receiving clonidine and dexmedetomidine. Hemodynamic parameters were measured and compared between the groups.
Results: The heart rate and the mean arterial pressure was significantly high in placebo group than that of the other two groups but the comparison between clonidine or dexmedetomidine group did not show significant difference in the hemodynamic parameters. Similarly the recovery time after extubation and the number of isoflurane dose requirements were also high among the placebo group when compared to the other two groups.
Conclusion: The measurement of hemostability parameters between the clonidine and dexmedetomidine did not show much variation, but considering clonidine being more cost effective than dexmedetomidine, it can be recommended for maintaining cardiovascular stability during laproscopic cholecystectomy.

Keywords: Clonidine, Dexmedetomidine, Cardiovascular stability.

Doi : 10.18231/j.ijca.2019.084

How to cite : Rajaprabu T, Kumar V, Comparison between the hemodynamic stability of dexmedtomidine and clonidine infusions among patients undergoing laproscopic cholecystectomy- A randomized controlled trial. Indian J Clin Anaesth 2019;6(3):437-440

Copyright © 2019 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)