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IP International Journal of Comprehensive and Advanced Pharmacology

A review on pain and its signals modulation by body

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Review Article

Author Details : Rashmi B.R*, Ebrahim N.K.C

Volume : 4, Issue : 3, Year : 2019

Article Page : 84-90

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Pain is an uncomfortable feeling that tells you something may be wrong. It can be steady, throbbing, stabbing, aching, pinching, or described in many other ways. Sometimes, it’s just a nuisance, like a mild headache. Other times it can be debilitating. Pain can bring about other physical symptoms, like nausea, dizziness, weakness or drowsiness. It can cause emotional effects like anger, depression, mood swings or irritability. Pain can change your lifestyle and impact your job, relationships and independence. Pain is classified as either acute or chronic. Acute pain is usually severe and short-lived, and is often a signal that your body has been injured. Chronic pain can range from mild to severe, is present for long periods of time, and is often the result of a disease that may require ongoing treatment. When we sense pain, we pay attention to our bodies and can take steps to fix what hurts. Pain also may prevent us from injuring a body part even more. If it didn't hurt to walk on a broken leg, a person might keep using it and cause more damage. If your throat is really sore, you'll probably go to the doctor, who can treat the infection if you have one. Pain itself often modifies the way the central nervous system processes pain, so that a patient actually becomes more sensitive and gets more pain with less provocation. This is called “central sensitization.” (And there’s peripheral sensitization too.) Sensitized patients are not only more sensitive to things that should hurt, but also to ordinary touch and pressure as well. Their pain also “echoes,” fading more slowly than in other people. This phenomenon is usually superimposed over other problems, but it can also occur acutely and be the primary issue, as in complex regional pain syndrome, or amplified pain syndrome, which disporportionately affects everyone.

Keywords: Pain, Nociceptors, Substance P, Kallikreins, Kinins, Opioids.

Doi : 10.18231/j.ijcaap.2019.018

How to cite : B.r R, N.k.c E, A review on pain and its signals modulation by body. IP Int J Compr Adv Pharmacol 2019;4(3):84-90

Copyright © 2019 by author(s) and IP Int J Compr Adv Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (