COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Print ISSN:-2394-2118

Online ISSN:-2394-2126


Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 519

Emailed: 0

PDF Downloaded: 185

Indian Journal of Clinical Anatomy and Physiology

Pattern of malformations in central nervous system and its association with other congenital anomalies in perinates

Full Text PDF Share on Facebook Share on Twitter

Author Details : Hari Charan Sarangsa, Jayanta Kumar Sarkar, Giriraj Kusre, Krishna Kanta Biswas

Volume : 5, Issue : 3, Year : 2018

Article Page : 314-319

Suggest article by email


Introduction: The congenital malformations of the central nervous system is one of the leading causes of perinatal mortality in this region of the country. It may present as an isolated defect or may be associated with other organ system malformations.
Aims and Objectives: Aim of the present study was to find out the pattern of congenital malformations in the central nervous system both in live and still born perinates. Our main objective was to ascertain its association with other organ systems most commonly involved.
Materials and Methods: The prospective study was carried out on 76 perinates having congenital anomalies out of 15,970 births (15,614 live born and 356 stillborn) ranging from 28th weeks of gestation to 7 days after birth. Twenty, out of 76 were born with central nervous system malformations.
Results and Observations: The congenital malformations of central nervous system were found to be 26.31%. Anencephaly was the most common malformation (50%) observed amongst the central nervous system in the study with a female preponderance 1.5:1, followed by spina bifida with meningomyelocele (35%), hydrocephalus (10%) and holoprosencephaly (5%). Anencephaly was associated with occipital meningoencephalocele in 10% cases.
Conclusion: Anencephaly is the most common malformations in the study, followed by spina bifida and meningomyelocele. The other malformations found in the central nervous system are hydrocephalus, meningoencephalocele and holoprosencephaly. The incidence of congenital malformations in present study is comparatively lower than in other parts of India and abroad.

Keywords: Congenital malformation, Perinates, Anencephaly, Spina bifida, Meningomyelocele.

Doi : 10.18231/2394-2126.2018.0073

How to cite : Sarangsa H C, Sarkar J K, Kusre G, Biswas K K, Pattern of malformations in central nervous system and its association with other congenital anomalies in perinates. Indian J Clin Anat Physiol 2018;5(3):314-319

Copyright © 2018 by author(s) and Indian J Clin Anat Physiol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (