COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Article view: 568

Article download: 180

Indian Journal of Clinical Anatomy and Physiology


Evaluation of umbilical cord arterial blood gas analysis in gestational diabetes mellitus


Full Text PDF Share on Facebook Share on Twitter


Author Details : Geena Augustine, Ranjith Sreedharan*, Ursula Sampson, Jithesh T.K, R. Manikumar

Volume : 5, Issue : 4, Year : 2018

Article Page : 508-514


Suggest article by email


Abstract

Gestational diabetes mellitus (GDM) represents glucose levels in the high end of the population distribution during pregnancy. GDM carries a high risk of adverse outcomes such as perinatal outcomes and a longer-term risk of obesity and glucose intolerance in offspring. Mothers with GDM have an excess of hypertensive disorders during pregnancy and a high risk of diabetes mellitus after that. This study aimed to evaluatethe influence of hypoxia status, haematological parameters, cord blood lactate, and birth weight of infants on GDM and its complications. The study was conducted on 100 pregnant women having Gestational Diabetes Mellitus (GDM), and the control population consists of 50 normal pregnancies. Samples included in this study were foetal cord blood and maternal blood. Parameters such as blood gases, lactate, haemoglobin, RBC count, red cell indices, and fetal birth weight were determined. No suggestive changes were found in pH of GDM neonates when compared to the healthy foetus.GDM offspring, when compared to the normal, showed a significant decrease in pO2 and pCO2.A relative reduction in O2saturation and O2 content in GDM foetus when compared to a healthyfoetus. Lactate level is significantly increased in GDM neonates when correlated to the control group. There is a striking change in haemoglobin, RBC count, total WBC count, MCV and MCH in GDM. The results also suggest a correlation of cord blood Hb, cord blood PCV and Cord blood pO2 with the birth weight of infants. Lower oxygen saturation and oxygen content and increased lactate concentrations in offspring of GDM mothers indeed emulate intensified fetal metabolism as an outcome of hyperglycaemia and hyperinsulinemia, and therefore these fetuses demandconstant supervision at term and during delivery.

Keywords: Gestational diabetes mellitus, Umbilical arterial cord blood, Hypoxic-ischemic event.

Doi : 10.18231/2394-2126.2018.0117

How to cite : Augustine G, Sreedharan R, Sampson U, T.k J , Manikumar R, Evaluation of umbilical cord arterial blood gas analysis in gestational diabetes mellitus. Indian J Clin Anat Physiol 2018;5(4):508-514

Copyright © 2018 by author(s) and Indian J Clin Anat Physiol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)