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International Journal of Clinical Biochemistry and Research

Evaluation of serum vitamin B12 level in patients of metabolic syndrome

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Research Article

Author Details : Prashant K Nichat, Sagar Dholariya*

Volume : 6, Issue : 4, Year : 2019

Article Page : 474-478

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Introduction: The metabolic syndrome (MetS) is a rising public-health problem and clinical challenge
worldwide. Vitamin B12 deficiency is associated with MetS. But its role as independent risk factor for
MetS is not clear. Objective of our study was to evaluate serum vitamin B12 levels in MetS cases and its
association with parameters of MetS
Material and Methods: Total 50 MetS cases and 50 age and sex matched healthy controls were included
in the study. Cases were selected according to new international diabetes federation (IDF) criteria of
MetS. Estimation of serum vitamin B12 were done on electrochemiluminescent machine immulite-1000
by electrochemiluminesce principle. Estimation of fasting blood sugar, triglyceride and HDL were done on
advia 1800 chemistry autoanalyzer. Waist circumference was measured by measuring tape. Blood pressure
was measured by sphygmomanometer.
Result: The median values of vitamin B12 in cases were 210 pg/ml with the interquartile difference of
293.75 and the median value of vitamin B12 in controls were 178 pg/ml with the interquartile difference
of 137.5. The differences between mean ranks of two groups were not significant (P=0.25). Vitamin B12
were found to be positively correlated with serum triglyceride (correlation coefficient 0.337; P=0.001) and
serum HDL level (correlation coefficient 0.207; P= 0.039).
Conclusion: There was no significant difference of serum vitamin B12 levels in metabolic syndrome
patients. Serum vitamin B12 was positively correlated with serum triglyceride and HDL level.

Keywords: Vitamin B12, Metabolic syndrome, Triglyceride, HDL.

Doi : 10.18231/j.ijcbr.2019.099

How to cite : Nichat P K, Dholariya S, Evaluation of serum vitamin B12 level in patients of metabolic syndrome. Int J Clin Biochem Res 2019;6(4):474-478

Copyright © 2019 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (