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International Journal of Clinical Biochemistry and Research


Study of Serum Lipoproteins and their role in senile dementia


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Research Article

Author Details : Balasaheb H Jadhav*, Madhav G kalekar, Syed A Jaweed, Pournima Mitkari

Volume : 7, Issue : 1, Year : 2020

Article Page : 19-24


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Abstract

Senile dementia is a neurodegeneration disease characterized by loss of memory, attention and cognitive
functions. Lipoproteins are large lipid and protein complexes that play a major role in carrier of lipophilic
and lipid molecule in plasma and central nervous system. The systemic hyperlipidemia may damage
the Blood brain barrier via inflammatory and other mechanisms, with consequent leakage of serum
lipoproteins. Inflammatory cytokines, and other amyloidogenic factors increases oxidative Stress and
has important role in attention, cognition. In the present study we evaluated the levels of lipoproteins
in Alzheimer’s dementia patients, and observed significantly higher levels of lipoproteins in Alzheimer’s
dementia patients compared to healthy controls (P<0> controls and 50 Alzheimer’s dementia patients by using standard methods.

Keywords: Alzheimer’s disease (AD), Amyloid (A ), neurofibrillary tangles (NFT), APOE E4, b b

Doi : 10.18231/j.ijcbr.2020.004

How to cite : Jadhav B H, Kalekar M G, Jaweed S A, Mitkari P, Study of Serum Lipoproteins and their role in senile dementia. Int J Clin Biochem Res 2020;7(1):19-24

Copyright © 2020 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)