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International Journal of Clinical Biochemistry and Research

Estimated protein output a novel reliable index in early prediction of renal failure

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Research Article

Author Details : K Alamelu Mangai, Vijaya Srinivasan*, Santhi Silambanan

Volume : 7, Issue : 1, Year : 2020

Article Page : 65-70

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Introduction: Assessment of proteinuria and albuminuria are the major core elements in diagnosis and
management of renal failure. Measurement of albumin: creatinine ratio has been chosen as the golden
standard for the determination of kidney failure.
Objective: The objective of the present study was to determine whether urine protein – creatinine ratio and
estimated protein output( EPO) can be use d as significant indices to identify kidney injury at an earlier
stage. To achieve this goal t he sensitivity, specificity and predictive values of urinary protein-creatinine
ratio were compared with urinary albumin: creatinine ratio and EPO.
Materials and Methods: Random urine samples were collected from 154 individuals aged between 25-65
years who attended the outpatient clinic at the hospital.
Results: The urinary protein - creatinine ratio had a sensitivity of 87% and specificity of 78% respectively.
Conclusion: The results substantiate that the urinary protein: creatinine ratio can be used as a reliable
and non-expensive marker to screen individuals a t risk of chronic kidney failure and quantification by
determining EPO is an accurate method to detect kidney failure at an earlier stage.

Keywords: Sensitivity, Specificity, Renal failure, Urine protein, Creatinine ratio, Urine albumin, Creatinine ratio, Estimated protein output (EPO)

Doi : 10.18231/j.ijcbr.2020.014

How to cite : Mangai K A, Srinivasan V, Silambanan S, Estimated protein output a novel reliable index in early prediction of renal failure. Int J Clin Biochem Res 2020;7(1):65-70

Copyright © 2020 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (