COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-6369

Online ISSN:-2394-6377

CODEN : IJCBK6

Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 1202

Emailed: 0

PDF Downloaded: 212

International Journal of Clinical Biochemistry and Research


Correlation of Cystatin C with Atherogenic Indices in South Indian Obese Individuals


Full Text PDF Share on Facebook Share on Twitter


Author Details : Rahul M. H, Deepa K, Varun Reddy, Sudhir, Shubha Jayaram

Volume : 2, Issue : 4, Year : 2015

Article Page : 229-232


Suggest article by email


Abstract

Introduction: Obesity is the leading cause for cardiovascular disease in the world. Cystatin C is a novel marker of cardiovascular disease and atherogenic indices which is used as an index for cardiac risk stratification. The objective of the study was to estimate the Cystatin C levels in non-obese and obese individuals aged between 18-39 years and to compare the levels of Cystatin C among these individuals. The study was also done with an objective to know the association of Cystatin C with atherogenic indices.
Methodology: The subjects were selected from healthy volunteers of Mysore aged between 18-39 years of either sex. They were grouped into two groups based on their BMI. Each group had sample size of 60. Sample were collected in fasting state and analyzed for Total Cholesterol, Triglyceride, LDL-Cholesterol & HDL cholesterol by enzymatic method and Cystatin-C by immune-turbidimetric method using Randox auto-analyzer.
Results and Interpretation: The mean serum Cystatin C level in non obese group was 0.7±0.03 mg/L, and in Obese group 1.15±0.09 mg/L (p value<0.001). Serum Cystatin C showed a positive correlation with serum triglycerides (r=0.7), Atherogenic index of plasma (AIP) (r=0.80), TCHOL: HDL (Castelli’s Risk Index I) (r=0.71), HDL: LDL (Castelli’s Risk Index II) (r=0.70) and Atherogenic coefficient (AC) {(Non HDLc)/HDLc} (r=0.60) respectively and negative correlation with serum HDL (r=-0.52).
Conclusion: Several indices have been derived from lipid profiles to establish an index for predicting the risk of having coronary event. Cystatin C, was strongly correlated with the Atherogenic index of plasma (AIP), hence AIP can be used as a better index for screening the preclinical Cardiovascular event in obese individuals as estimation of Cystatin C is cost effective.

Key Words: Atherogenic Index of Plasma (AIP), Atherogenic coefficient (AC), Castelli’s Risk Index (CRI), Cystatin C, Obesity.

How to cite : Rahul M. H, Deepa K, Reddy V, Sudhir, Jayaram S, Correlation of Cystatin C with Atherogenic Indices in South Indian Obese Individuals. Int J Clin Biochem Res 2015;2(4):229-232

Copyright © 2015 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)