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CODEN : IJCBK6

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International Journal of Clinical Biochemistry and Research


Study of malondialdehyde and estimation of blood glucose levels in patients with diabetes mellitus with cataract


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Author Details : Syeda Shahana Jalees, M. Rosaline

Volume : 4, Issue : 3, Year : 2017

Article Page : 319-323


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Abstract

Increased oxidative stress may contribute to development of complications in diabetes may result from over production of precursors to reactive oxygen radicals and/ or decreased efficiency of inhibitory scavenger systems. Senile diabetic cataract is one of the chronic complications of diabetes mellitus. The present study has been carried out in patients suffering with NIDDM (Type-2) with or without associated cataract. Hyperglycemia causes oxidative stress, as measured by malondialdehyde (MDA) (a lipid peroxidation product) is more in diabetic patients (370.80 n.mol/l) compared to the normal individuals (181.04 n.mol/l) whereas the oxidative stress in diabetics with cataract is significantly more (399.12 n.mol/l) than that in diabetics without complications. Attempts have been made under present study to estimate serum MDA levels as a marker of free radical stress against free radical injury.

Keywords:
Diabetes mellitus, Cataract, Malondialdehyde

How to cite : Jalees S S, Rosaline M, Study of malondialdehyde and estimation of blood glucose levels in patients with diabetes mellitus with cataract. Int J Clin Biochem Res 2017;4(3):319-323

Copyright © 2017 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)