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Print ISSN:-2394-6369

Online ISSN:-2394-6377

CODEN : IJCBK6

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International Journal of Clinical Biochemistry and Research


Susceptibility of diabetics with superoxide dismutase gene 2 polymorphism to cardiovascular complications


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Author Details : M. C. Archana, Minu Meenakshi Devi K. R.

Volume : 5, Issue : 2, Year : 2018

Article Page : 191-195


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Abstract

Introduction: Diabetes mellitus is the most important cause for vascular diseases of heart and brain. The major factor in the development of diabetic complications is oxidative stress. Superoxide dismutases (SODs) are the enzymes which play a primary role against oxidative stress. A polymorphism C/T substitution producing TT genotype in superoxide dismutase 2 gene causes impaired targeting of the SOD 2 enzyme, resulting in reduced activity of the enzyme inside mitochondria. This can lead to increased oxidative stress in these patients making them susceptible to cardiovascular complications
Aim:Our study is performed to analyse if there is increased susceptibility of diabetics with SOD2 gene polymorphism to cardiovascular complications and to assess if this SOD2 polymorphism causes reduced SOD activity.
Materials and Methods: 30 cases of diabetics with cardiovascular disease, 30 cases of diabetics without cardiovascular disease and 30 healthy controls are included in the study. Genotype analysis by PCR and RFLP and serum superoxide dismutase activity is measured by spectrophotometer.
Results:TT genotype is more frequently distributed and Serum SOD activity is reduced among diabetics with CVD compared to diabetics without CVD and controls ,which shows an increased risk of cardiovascular complications among diabetics with SOD2(GCT/GTT) gene polymorphism.
Conclusion: TT genotype is an independent risk factor for the development of cardiovascular complications in diabetes. Patients with TT genotype have reduced level of serum superoxide dismutase that may cause increased oxidative stress, the main mechanism for development of cardiovascular complications in diabetes.

Keywords: Diabetes, Cardiovascular disease, Oxidative stress, Superoxide dismutase 2 gene polymorphism

Doi : 10.18231/2394-6377.2018.0039

How to cite : Archana M C, Minu Meenakshi Devi K. R., Susceptibility of diabetics with superoxide dismutase gene 2 polymorphism to cardiovascular complications. Int J Clin Biochem Res 2018;5(2):191-195

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)