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International Journal of Clinical Biochemistry and Research


Variations in serum malondialdehyde levels in patients with leukemia


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Author Details : K. N. Pujari, S. P. Jadkar, C. G. Patil, Aruna Kulkarni, V. B. Tuljapurkar

Volume : 5, Issue : 2, Year : 2018

Article Page : 254-256


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Abstract

Leukemias are malignant neoplasms of hematopoietic stem cells characterized by diffuse infiltration of the blood and bone marrow by neoplastic cells. Leukemias are classified as acute and chronic according to clinical course and myeloid and lymphoid according to the cell predominantly involved in leukemic process. Free radicals are implicated in the pathogenesis of leukemia. Oxidative destruction of polyunsaturated fatty acid is called as lipid peroxidation. In this study, we determined serum malonyldialdehyde (MDA) level as a lipid peroxidation product in patients with leukemia. The mean serum MDA levels were significantly increased in leukemic patients (p<0>significant difference in serum MDA levels with respect to sex only in patients with chronic myeloid leukemia. Whereas in age groups, we found significant trend in serum MDA levels in patients with CML, AML and ALL patients. There was no significant difference in serum MDA level in patients with CLL with respect to age. Our finding of the high levels of serum malondialdehyde in leukemic patients as compared to healthy control may be due to increased oxidative stress in patients with leukemia.

Keywords: Malondialdehyde, Leukemia, Oxidative stress

Doi : 10.18231/2394-6377.2018.0052

How to cite : Pujari K N, Jadkar S P, Patil C G, Kulkarni A, Tuljapurkar V B, Variations in serum malondialdehyde levels in patients with leukemia. Int J Clin Biochem Res 2018;5(2):254-256

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)