mg/dl & 13.62 ± 6.17 U/L (p > 0.05), borderline increased. They are statistically insignificant. Conclusion: These findings suggest that cardial lipo peroxidation may be common event following brief episodes of myocardial ischemia and support a role for antioxidant therapy in patients after PTCA. Keywords: Percutaneous Transluminal Coronary Angioplasty, Oxidative Stress, Antioxidant "/>

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International Journal of Clinical Biochemistry and Research


Effect of percutaneous transluminal coronary angioplasty on oxidants and antioxidants in patients with coronary artery disease


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Author Details : Ranjeet U. Jadhav, G. J. Belwarkar, P. E. Jagtap, S. P. Dhonde, N. S. Nagane

Volume : 5, Issue : 2, Year : 2018

Article Page : 268-270


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Abstract

Introduction: Percutaneous transluminal coronary angioplasty (PTCA) has become a common intervention in coronary artery disease (CAD), relieving symptoms such as angina and improving myocardial function. There is short term injury to the heart after PTCA; which can take in the form of reperfusion arrhythmias or myocardial stunning or both. Production of oxygen derived free radical potentially cytotoxic species which can be formed may be controlled by naturally occurring antioxidant defence. In this study we investigated the alterations in oxidative and antioxidative status after PTCA by estimating Malondialdehyde (MDA) as marker of oxidative stress, Superoxide Dismutase (SOD) and vitamin C for antioxidant status and myocardial cell damage by Creatine Phosphokinase total (Cpk-total) and Creatine Phosphokinase-MB (Cpk-MB).
Materials and Methods: 120 patients of CAD, subjected to PTCA were included in the study. MDA, SOD, Vitamin C, Cpk total and Cpk-MB levels were measured after PTCA in patents.
Result: There were increased levels of SOD & Cpk-total, 4.94 ± 0. Units / ml & 119.46 ± 40.51 U/L, (p < 0 style="color:black">mg/dl & 13.62 ± 6.17 U/L (p > 0.05), borderline increased. They are statistically insignificant.
Conclusion: These findings suggest that cardial lipo peroxidation may be common event following brief episodes of myocardial ischemia and support a role for antioxidant therapy in patients after PTCA.

Keywords: Percutaneous Transluminal Coronary Angioplasty, Oxidative Stress, Antioxidant

Doi : 10.18231/2394-6377.2018.0055

How to cite : Jadhav R U, Belwarkar G J, Jagtap P E, Dhonde S P, Nagane N S, Effect of percutaneous transluminal coronary angioplasty on oxidants and antioxidants in patients with coronary artery disease. Int J Clin Biochem Res 2018;5(2):268-270

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)