COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Article view: 321

Article download: 112

International Journal of Clinical Biochemistry and Research


Estimation of serum uric acid, urinary calcium-creatinine ratio and microalbuminuria in prediction of pre-eclampsia


Full Text PDF Share on Facebook Share on Twitter


Author Details : Lekha Tejaswi Y, Preethi BP

Volume : 5, Issue : 2, Year : 2018

Article Page : 277-283


Suggest article by email


Abstract

Introduction: The present study was aimed at evaluating serum uric acid, urinary calcium to creatinine ratio and microalbuminuria as predictors of pre-eclampsia in asymptomatic pregnant females.
Materials and Methods: 100 asymptomatic pregnant females were screened for uric acid, urinary calcium to creatinine ratio and microalbuminuria between 20-24weeks of their gestation and were followed up till delivery. BP was recorded and proteinuria evaluated by dipstick method. Our observations were subjected to statistical analysis by evaluating diagnostic accuracy and Receiver Operating Characteristic curve of uric acid, urinary calcium to creatinine ratio and microalbuminuria.
Results:Calcium creatinine ratio (94%) and microalbuminuria (89%) turned out to have good specificity, negative predictive value remained high for calcium creatinine ratio (97%), microalbuminuria (95%) and serum uric acid (91%). Area under the curve for calcium creatinine ratio is highest when compared to microalbuminuria and serum uric acid, making it an excellent predictor.
Conclusion: Our study findings suggest that calcium creatinine ratio was an excellent predictor of preeclampsia followed by microalbuminuria which was a good test for preeclampsia and serum uric acid which turned out to be a fair predictor of preeclampsia. We conclude that calcium creatinine ratio and microalbuminuria as early predictors of preeclampsia and can be used for screening purpose.

Keywords: Pre-Eclampsia, Serum Uric Acid, Microalbuminuria, Urinary Calcium-Creatinine Ratio

Doi : 10.18231/2394-6377.2018.0057

How to cite : Lekha Tejaswi Y, Preethi Bp, Estimation of serum uric acid, urinary calcium-creatinine ratio and microalbuminuria in prediction of pre-eclampsia. Int J Clin Biochem Res 2018;5(2):277-283

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)