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International Journal of Clinical Biochemistry and Research


Markers of atherosclerotic risk in patients with non-alcoholic fatty liver disease: A preliminary study


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Author Details : Roopa Rani Bhandary, Sukanya Shetty, Ashalatha Rao, Srikrishna U

Volume : 5, Issue : 2, Year : 2018

Article Page : 328-333


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Abstract

Introduction: The prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) is rising continuously. Cardiovascular disease is one among the leading causes of morbidity and premature mortality in patients with NAFLD.
Aims and Objectives: To determine the risk of atherosclerosis in NAFLD subjects diagnosed by USG at K.S.Hegde Charitable hospital.
Materials and Methods:A cross-sectional study involving 203 persons diagnosed with NAFLD were included in the study. Subjects with alcoholic liver disease, renal failure, tuberculosis, hepatitis B and/or C and those on lipid lowering drug were excluded from the study. Lipid profile was measured and Atherogenic Index of Plasma (AIP) was calculated as log (TG/HDL-c). Categorization of the subjects with respect to risk of atherosclerosis was done based on serum LDL-c, non HDL-c and AIP. Statistical analysis was done using Chi Square test and p value < 0>
Results: More than normal values were observed for serum total cholesterol, LDL-c, triglyceride and non HDL-c   in high percentage of NAFLD subjects (76.8%, 84.7%, 70.4% and 72.4% respectively). Serum HDL-c level was low in 53.2% subjects. 51.2% of subjects had high AIP and 23.6% had moderately high AIP.
Conclusion: Results of categorization of the subjects with respect to risk of atherosclerosis based on serum LDL-c, non HDL-c and AIP showed that high percentages of subjects were in moderate and high risk categories. AIP is probably a better marker to determine the risk of atherosclerosis.

Keywords: Atherogenic index of plasma, NAFLD, Non-alcoholic fatty liver disease, Lipids, Cardiovascular.

Doi : 10.18231/2394-6377.2018.0068

How to cite : Bhandary R R, Shetty S, Rao A, Srikrishna U, Markers of atherosclerotic risk in patients with non-alcoholic fatty liver disease: A preliminary study. Int J Clin Biochem Res 2018;5(2):328-333

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)