COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-6369

Online ISSN:-2394-6377

CODEN : IJCBK6

Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 377

Emailed: 0

PDF Downloaded: 112

International Journal of Clinical Biochemistry and Research


Association of inflammation with endothelial dysfunction in pregnancy induced hypertensive women


Full Text PDF Share on Facebook Share on Twitter


Author Details : J. Visalasree, Phlips Abraham

Volume : 5, Issue : 2, Year : 2018

Article Page : 348-352


Suggest article by email


Abstract

Introduction: Pregnancy induced hypertension is considered as the major cause of maternal and perinatal mortality. Even though occurrence of PIH is due to abnormal placentation, endothelial dysfunction (ED) plays a pivotal role in the genesis of the multisystem disorder that develops in pre eclampsia and eclampsia. Excessive inflammation might lead to ED. So, a study has been designed to analyse some inflammatory markers (TNF-?, HsCRP, IL-6) and their association with endothelial dysfunction (NO) in PIH women.
Materials and Methods:Study group consisted of Normotensive pregnant women (N) preclamptic women (PE) and eclamptic women (E) with 100 subjects in each group in the 3rd trimester of pregnancy. They were investigated for TNF-?, IL-6, HsCRP & NO. Statistical analysis was done using ANOVA
Results:When compared to controls TNF-?, IL-6, HsCRP levels were found to be significantly high & NO levels were significantly low in PE, E group. Eclamptic women showed a significantly high level of TNF-?, and low levels of NO when compared to PE group.
Conclusion:Early careful monitoring of TNF-? along with NO might be helpful to predict the origination and advancement of the disease. It may help in emerging approaches for diagnosis and prevention of maternal and fetal complications.

Keywords: PIH- Pregnancy induced hypertension, TNF-? – Tumor necrosis factor-alpha, IL-6 – Interleukin-6, HsCRP-High sensitive C-reactive protein, NO- Nitric oxide

Doi : 10.18231/2394-6377.2018.0072

How to cite : Visalasree J, Abraham P, Association of inflammation with endothelial dysfunction in pregnancy induced hypertensive women. Int J Clin Biochem Res 2018;5(2):348-352

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)