COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 597

Article download: 177

International Journal of Clinical Biochemistry and Research

Biochemical markers for early senescence of erythrocyte membrane in type 2 diabetes mellitus

Full Text PDF Share on Facebook Share on Twitter

Author Details : Asfia Afreen, Dinesh Javarappa

Volume : 5, Issue : 3, Year : 2018

Article Page : 445-448

Suggest article by email


Diabetes mellitus is an ice berg of disease resulting due to impairments in insulin secretion, insulin action or both. Hyperglycemia caused due to the above defects leads to complications like neuropathy, nephropathy, retinopathy, peripheral vascular disease and coronary artery disease as a result of stimuli for oxidative stress on cell-membrane. The aim of the study is to establish a relation between the stress induced by oxidants bringing changes with the erythrocyte membrane. The protein content, protein thiols, protein carbonyl levels in relation to control of type 2 DM based on HbA1C level indicates that there is an auto-oxidation of glucose which results in persistent production of thiols and carbonyl leading to protein damage, modification due to amino acid residues, fragmentation of amino acid stress and raised proteolytic susceptibility. Protein thiols and carbonyl are the results of oxidation of amino acid which is non-specific or by specific amino acid oxidation.
 A case control comparative study was done with type 2 DM and normal control at BMCH & RC, Chitradurga. The maximum number were of the age group of 41-45 i.e. 32%. The mean FBS levels among cases and controls 197.50 mg/dl and 93.48 mg/dl respectively. There was significant difference between levels of protein content (4.56±0.19), protein carbonyl (1.20±0.08) and protein thiol levels (1.42±0.10) among diabetics in comparison to protein content (5.40±0.31), protein carbonyl (0.90±0.06), and protein thiols (2.12±0.12) in controls. It was found that there was significant increase of protein carbonyl, decrease protein content and decrease in protein thiols in diabetic patients.

Keywords: Diabetes mellitus, Oxidative stress, Reactive oxygen species, Protein content, Protein carbonyl, Protein thiols.

Doi : 10.18231/2394-6377.2018.0094

How to cite : Afreen A, Javarappa D, Biochemical markers for early senescence of erythrocyte membrane in type 2 diabetes mellitus. Int J Clin Biochem Res 2018;5(3):445-448

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (