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International Journal of Clinical Biochemistry and Research


Cystatin C, oxidative stress and body fat distribution in the middle aged individuals with coronary artery disease


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Author Details : P Srilakshm*, Y V Ramakrishna Reddy, K Rambabu, S Venkat Rao

Volume : 5, Issue : 4, Year : 2018

Article Page : 622-626


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Abstract

Introduction: Oxidative stress plays an important role in the progression of atherosclerosis, it is the principal cause for coronary artery disease (CAD). Lipid peroxidation product Malondialdehyde (MDA) is an index of oxidative stress. To assess the oxidative stress, MDA and total antioxidant capacity (TAC) are estimated. Body fat distribution was assessed by obesity and blood lipids, which in turn was measured by Body mass index (BMI) and waist circumference (WC). Cystatin C was measured as an emerging cardio vascular risk factor.
Materials and Methods: Study consists of two groups, 145 subjects diagnosed with CAD are included in study group and 66 age and sex matched subjects (non CAD) are included in control group.
Results: In this study, Cystatin C is highly significant observed in CAD cases than controls. BMI and WC are not significantly increased; whereas significant increase in mean MDA and decrease in mean TAC levels.
Conclusion: Oxidative stress is markedly observed in CAD cases, due to toxic effects of ROS. Increase in Cystatin C levels significantly correlated with WC in middle aged individuals.

Keywords: Coronary artery diseases, Cystatin C, Malondialdehyde, Oxidative stress, Total antioxidant capacity.

Doi : 10.18231/2394-6377.2018.0132

How to cite : Srilakshm P, Reddy Y V R, Rambabu K, Rao S V, Cystatin C, oxidative stress and body fat distribution in the middle aged individuals with coronary artery disease. Int J Clin Biochem Res 2018;5(4):622-626

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)