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International Journal of Clinical Biochemistry and Research


Abnormalities of liver enzymes in HIV positive patients on antiretroviral therapy


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Author Details : N Ashakiran*, V A.R Satyanarayana, M Ravikanth, P S Girish Kumar

Volume : 6, Issue : 1, Year : 2019

Article Page : 61-63


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Abstract

Introduction: Liver disease is considered as one of the main health concern in Human Immunodeficiency Virus (HIV) patients. Diseases of the liver in HIV patients encompass spectrum of liver abnormalities. Elevated levels of liver enzymes like aspartate transaminase (AST), alanine transaminase (ALT) and alkaline Phosphatase (ALP) are markers of hepatocyte injury. The aim of the present study was to evaluate the clinical significance of liver enzymes such as AST, ALT and ALP in HIV patients on antiretroviral therapy.
Materials and Methods: In this cross sectional case-control study, a total of 180 subjects were included in this study. Among them 90 HIV positive patients were included as cases and 90 normal subjects were included as controls. Seropositivity of all 90 HIV patients was confirmed by HIV TRI-DOT test. Estimation of serum AST, ALT and ALP was done by using automated chemistry analyzer. P value <0>
Results: In this study, there is a significant elevation in liver enzymes such as AST, ALT and ALP (p<0>
Conclusion: In this study, we conclude that, significantly elevated levels of liver enzymes is observed in HIV positive patients under the treatment. Therefore, the elevated levels of liver enzymes should be analyzed and monitored in HIV patients to prevent further progression of disease.

Keywords: CD4+ cells, Liver disease, HIV, Hepatotoxicity, Anti-retroviral therapy.

Doi : 10.18231/2394-6377.2019.0016

How to cite : Ashakiran N, Satyanarayana V A, Ravikanth M, Kumar P S G, Abnormalities of liver enzymes in HIV positive patients on antiretroviral therapy. Int J Clin Biochem Res 2019;6(1):61-63

Copyright © 2019 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)