COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Article view: 357

Article download: 195

International Journal of Clinical Biochemistry and Research

Role of HbA1c and microalbuminuria in diabetic-hypertensive individuals: An index for the diabetic nephropathy

Full Text PDF Share on Facebook Share on Twitter

Author Details : P Srilakshmi*, Rama Krishna Reddy Y. V, Prathibha Bharathi K, K Rambabu

Volume : 6, Issue : 1, Year : 2019

Article Page : 126-128

Suggest article by email


Introduction: The present study was carried out to assess the influence of advanced glycosylation end products, microalbuminuria, and hypertension in development of nephropathy in diabetic-hypertensive individuals. Microalbuminuria has been shown to be a risk factor for nephropathy in patients with type 2 diabetes with uncontrolled glycemic index. In this study, we aimed to explore the association advanced glycosylated end products between microalbuminuria and other risk factors in the development of diabetic nephropathy in diabetic-hypertensive individuals.
Materials and Methods: A total of 131 individuals were randomly recruited in the study and were segregated into three groups. Group-1 is normal (n=50) and group-II contains control DM (n=22) and group-III contains uncontrolled DM (n=59). Medical records were used to collect data of age, SBP, DBP and history of diabetes, hypertension. Blood samples were collected to estimate FBS, PPBS, glycosylated hemoglobin (HbA1C), and urine for estimation the urinary albumin.
Result: The FBS, PPBS, SBP has shown a significant rise between the controls and uncontrolled diabetes, where as DBP has show significant rise in the controlled diabetes in caparison to control group. Microalbuminuria and HbA1c has shown a significant rise in control diabetes and uncontrolled diabetes group when compared with control group. Microalbuminuria has shown a significant correlation with SBP, FBS, PPBS and HbA1c. ROC analysis indicates HbA1c and microalbuminuria are good markers for diabetic nephropathy.
Conclusion: Increased levels of microalbuminuria and advanced glycosylated end products will increase the compliance of diabetic-hypertensive individuals for developing the nephropathy.

Keywords: Diabetes, Glycated hemoglobin, Microalbuminuria.

Doi : 10.18231/2394-6377.2019.0030

How to cite : Srilakshmi P, Rama Krishna Reddy Y. V, Prathibha Bharathi K, Rambabu K, Role of HbA1c and microalbuminuria in diabetic-hypertensive individuals: An index for the diabetic nephropathy. Int J Clin Biochem Res 2019;6(1):126-128

Copyright © 2019 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (