COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2394-6369

Online ISSN:-2394-6377

CODEN : IJCBK6

Current Issue

Year 2020

Volume: 7 , Issue: 1

Article Access statistics

Viewed: 515

Emailed: 0

PDF Downloaded: 163

International Journal of Clinical Biochemistry and Research


Neutrophil to Lymphocyte Ratio as an Indicator of Presence of Coronary Artery Disease in Diabetic Patients


Full Text PDF Share on Facebook Share on Twitter


Author Details : Mario Leesha Fernando, Santhi Silambanan, Jothi Malar

Volume : 2, Issue : 3, Year : 2015

Article Page : 143-147


Suggest article by email


Abstract

Background and Objectives: Cardiovascular disease is the leading cause of death in type 2 Diabetes mellitus (DM). Type 2 DM is a significant risk factor of atherosclerotic coronary artery disease. Neutrophil to Lymphocyte ratio (NLR), an indicator of systemic inflammation has been shown to provide a reliable inflammatory index to be used in prognostic stratification of CAD. The objective of this study is to investigate the relationship between neutrophil to lymphocyte ratio (NLR) and coronary artery disease (CAD) in diabetic patients.

Methods: 100 diabetic patients who had coronary lesion with diameter stenosis of at least 50% and 50 diabetic patients with normal coronary anatomy matched with age and sex were retrospectively selected and classified as CAD(+) and CAD(-) group respectively. Diabetics with chronic infections and inflammation were excluded. NLR in two groups were compared.
Results: NLR was higher in CAD (+) group compared to CAD (-) group (p = 0.000). ROC curve analysis revealed that NLR value of ≥ 2.26 identified the presence of CAD in diabetic patients with 100% specificity and 92% sensitivity.
Conclusion: NLR was higher in diabetic patients with angiographically proven CAD compared to those without CAD. NLR may serve as a useful marker to predict the presence of CAD in type 2 diabetic patients.

Key words: Diabetes mellitus, Coronary artery disease, Neutrophil to Lymphocyte ratio

How to cite : Fernando M L, Silambanan S, Malar J, Neutrophil to Lymphocyte Ratio as an Indicator of Presence of Coronary Artery Disease in Diabetic Patients. Int J Clin Biochem Res 2015;2(3):143-147

Copyright © 2015 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)