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International Journal of Clinical Biochemistry and Research


Comparison of hepatic and renal parameters between Diabetic and Non Diabetic Individuals of Dakshina Kannada: A cross sectional study


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Research Article

Author Details : Mahalaxmi S Petimani, Greeshma B Kotian*, Prabhakar Adake

Volume : 6, Issue : 3, Year : 2019

Article Page : 344-347


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Abstract

Objectives: To compare fasting plasma glucose levels, HbA1c, hepatic and renal parameters in diabetes
mellitus (DM) subjects and compare the values with healthy controls.
Materials and Methods: A total of 67 (n=67) reports were collected from Central laboratory, Yenepoya
Medical College Hospital, Mangaluru from January 2018 to June 2018. Patients with FBS values more than
126mg/dl or HbA1c more than 6.5% who have been advised LFT and RFT by the physician were included
in diabetic group (34) and other 33 reports of LFT & RFT with normal FBS & HbA1c levels included in
non-diabetic group. All the data viz. FBS, HbA1c, Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, S
GOT, SGPT, Blood Urea and S. creatinine values were entered in excel sheet and subjected for statistical
analysis.
Results: Intergroup comparison of biochemical parameters was done by Non-Parametric test (Mann-
Whitney) and Pearsons Chi square tests. The values fmean inter quartile range (IQR)g of FBS, HbA1c,
Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, SGOT, SGPT, Blood urea and S. Creatinine in diabetic
group are 184.5mg(171-274.5 ), 8.9% (7.2-10.5), 0.7mg (0.5-0.8), 0.3mg(0.2-0.4), 0.4mg (0.3-0.4), 28U
(21.5-33), 25.5U(20-32.25), 30.5mg (21.75-38) and 0.9mg (0.8-1) respectively obtained in Mann-Whitney
test. Similarly, values of 96mg (78-103), 5.8% (5.3-5.9), 0.5 mg (0.4-0.7), 0.2mg (0.2-0.2), 0.3mg(0.2-
0.45), 23U (20-28), 24U (19-36), 18mg(16-21), and 0.7mg(0.6-0.8) were respectively noted in non-diabetic
group. The Mann-Whitney test showed significant difference in all the parameters except in Indirect
Bilirubin, SGOT, and SGPT levels between two groups (p<0> revealed there is revealed no significant difference in these parameters between diabetic and non-diabetic
group with p >0.05.
Conclusion: The present study suggests that there is no statistical significant difference in hepatic and
renal parameters between diabetic and non-diabetic groups with respect to Chi-square test. Many previous
studies have shown significant organ dysfunction in diabetic individuals, but our study result revealed there
is no difference in the biochemical parameters of diabetic and non-diabetic individuals.

Keywords: Diabetes Mellitus, Hepatic parameters, Renal parameters, Chisquare test, Mann Whitney test.

Doi : 10.18231/j.ijcbr.2019.075

How to cite : Petimani M S, Kotian G B, Adake P, Comparison of hepatic and renal parameters between Diabetic and Non Diabetic Individuals of Dakshina Kannada: A cross sectional study. Int J Clin Biochem Res 2019;6(3):344-347

Copyright © 2019 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)