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International Journal of Clinical Biochemistry and Research


Evaluation of electrophoretic pattern in renal disease: A retrospective study


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Case Report

Author Details : Dyna Ann Roby, Sukanya Shetty*, Roopa Bhandary

Volume : 6, Issue : 3, Year : 2019

Article Page : 437-441


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Abstract

Introduction: Protein electrophoresis is a technique that is well established and used for separating
proteins based on their net shape, size and charge. Plasma proteins are separated into bands or zones
according to their electric charge in an electrical field. Protein electrophoresis of the serum and urine along
with other investigations are used for the evaluation of patients with chronic kidney diseases. The varied
patterns of electrophoretographs observed in chronic kidney diseases brought to our attention to analyse
the electrophoretic patterns in chronic kidney diseases retrospectively in the clinical laboratory.
Materials and Methods: The present study evaluated the electrophoretic pattern in renal disease for the
period of 3 years. A total of 250 samples diagnosed for renal diseases were received by the laboratory for
electrophoretic analysis.
Results: Out of the 250 samples, 78(51.2%) had low albumin levels and 50(20%) samples showed alpha2-
beta bridging, 60 (24%) had high gamma globulins levels. Among the 50 samples who showed alpha2-beta
bridging, 37 were diagnosed for multiple myeloma, 9 for Chronic kidney disease, 2 for acute kidney injury,
2 with systemic hypertension and type II diabetes mellitus and 2 with pancytopenia.

Keywords: a2- b =alpha2-beta, b 2-M=beta 2 microglobulin, MM=multiple myeloma, HTN=hypertension, DM=diabetes mellitus, CKD=chronic kidney disease.

 

Doi : 10.18231/j.ijcbr.2019.092

How to cite : Roby D A, Shetty S, Bhandary R, Evaluation of electrophoretic pattern in renal disease: A retrospective study. Int J Clin Biochem Res 2019;6(3):437-441

Copyright © 2019 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)