COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 14th April 2020. As a result, our offices will now be closed till 14th April 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804

Article view: 617

Article download: 194

IP Indian Journal of Conservative and Endodontics


Role of prions in endodontics -“A Review”


Full Text PDF Share on Facebook Share on Twitter


Author Details : Atul Jain, Anukreti Agrawal*, Rachana Bahuguna, Deepa Davis, Shantwana Singh

Volume : 3, Issue : 3, Year : 2018

Article Page : 55-58


Suggest article by email

Abstract

Endodontic treatment could result in cross infections, from prions. This could result by transmission as a result of inadequate sterilisation of the previously used endodontic instruments in an infected individual. A review search was carried out online and 47 articles were found. Based on the preselected inclusion and exclusion criteria 22 articles were selected.

The normal prion protein is found throughout the body and is non-infectious. As a result of conversion in the protein structure is transformed to an infectious form. The latter results in various diseases can be carried out. Identification of the prion diseases can be carried out with the help of specific biomarkers, found in tissue or body fluid.

Prion diseases cannot be cured but there progress might be slowed down. The most effective form of treatment for these diseases is prevention of transmission, which could be carried out by proper sterilisation and infection control.

These diseases run a rapid course with majority of patients dying within a year. During endodontic treatment, files used for biomechanical preparation are highly susceptible towards adherence of this entity, owing to their unique configuration. The normal sterilisation process is not adequate to eliminate the infectious form of the prions. Another major source of cross infection is the air retention system in dental and suction unit.
Prion diseases are a group of fatal neurodegenerative disorders with no known cure. Adequate precautions inspread of the infection form of prions during endodontic treatment, is the most effective way of preventing these diseases.

Keywords: Scrapie disease, Creutzfeldt–Jakob disease, Transmissible spongiform encephalopathies, Misfolded PrP

Doi : 10.18231/2456-8953.2018.0015

How to cite : Jain A , Agrawal A , Bahuguna R , Davis D , Singh S , Role of prions in endodontics -“A Review”. IP Indian J Conserv Endod 2018;3(3):55-58

Copyright © 2018 by author(s) and IP Indian J Conserv Endod. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)