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IP Indian Journal of Conservative and Endodontics


Biomarker of health and disease in Dentistry: Proteomics


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Review Article

Author Details : Vamsee Krishna N*, Madhuri Nadhamuni

Volume : 4, Issue : 3, Year : 2019

Article Page : 69-74


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Abstract

Every living organism contains ‘Proteins’ which are building blocks to perform various functions. Proteomics is the analysis of the whole protein in a genome which tells about the molecular mechanisms of homeostatic cell and regarding external disturbances, such as pathologic or pharmacologic treatment. Proteomics improvized various biomedical fields such as medicine, dentistry, molecular biology, and genetics. This article reviews some of the currently available literature on conducting Proteomic analysis of dental tissues. A literature review is done using electronic databases, such as “PubMed,” “Google Scholar,” and “Scopus,” using keywords “Proteomics,” and “Biomarkers.” Furthermore, an advanced or refined search was carried out using the keywords “Mass Spectrometry,” “Proteins,” “Enamel,” “Dentin,” “Cementum,” “Periodontal ligament” and “pulp.” Proteomics in dentistry helps in the early diagnosis of health-disease molecular signatures with the discovery and recognition of numerous biomarkers in biological, pathological or pharmacological processes that are present in the fluids of the oral cavity. This paper explains the role of proteomics in the analysis of oral tissues.

Keywords: Proteomics, Mass Spectrometry, Biomarkers.

Doi : 10.18231/j.ijce.2019.016

How to cite : Vamsee Krishna N, Nadhamuni M, Biomarker of health and disease in Dentistry: Proteomics. IP Indian J Conserv Endod 2019;4(3):69-74

Copyright © 2019 by author(s) and IP Indian J Conserv Endod. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)