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IP Indian Journal of Clinical and Experimental Dermatology


Patterned wound healing effect of topical recombinant human epidermal growth factor in trophic ulcers secondary to leprosy


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Author Details : P. Saraswathy, V. Anandan, S. Kopika

Volume : 4, Issue : 2, Year : 2018

Article Page : 137-141


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Abstract

The aim of this study was to evaluate the wound healing effect of topical recombinant human Epidermal Growth Factor (Rh EGF) in trophic ulcers in leprosy patients. 40 patients, 29 males and 11 females, were included in the study. Re-epithelialization started on the 7th day, most of it occurred from the 2nd week onwards. Symmetric concentric hyperkeratosis started from the periphery and migrated towards the centre. In 4th to 5th week, complete uniform healing was noted with shedding of the overlying hyperkeratotic plaque. There was faster wound healing with excessive uniform keratosis that eventually desquamated, Ulcers healed with minimal healthy scar formation (almost scar free closure) and subsequent longer ulcer free interval. Overall it can be concluded from this study that topical Rh EGF is effective in promoting faster and better wound repair.

 Keywords: Wound healing, Epidermal growth factor, Trophic ulcer.

Doi : 10.18231/2581-4729.2018.0031

How to cite : Saraswathy P, Anandan V, Kopika S, Patterned wound healing effect of topical recombinant human epidermal growth factor in trophic ulcers secondary to leprosy. IP Indian J Clin Exp Dermatol 2018;4(2):137-141

Copyright © 2018 by author(s) and IP Indian J Clin Exp Dermatol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)