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Indian Journal of Clinical and Experimental Ophthalmology

Office investigations for myasthenia gravis: comparative analysis

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Research Article

Author Details : S R Lavanya*, Padmavathy , Ramakrishnan

Volume : 6, Issue : 1, Year : 2020

Article Page : 74-79

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Introduction: The purpose was to study the diagnostic yield of the various tests including lid fatigue
test, Cogan twitch, Rest test, Ice test and Repetitive nerve stimulation (RNS) study in clinically diagnosed
myasthenic patients.
Materials and Methods: A prospective study of newly diagnosed myasthenic patients was done at tertiary
eye - care centre. Totally, 58 patients underwent tests for the confirmation of myasthenia gravis. Fishers
Exact test was used for comparative analysis.
Results: Average age of presentation was 44.13 years. Number of male and female were 33 (56.9%) and
25 (43.1%). 8 (13.8%) patients were under the age of 15 years. Variability was observed in 47/58 (81.04%)
patients and Fatigue was seen in 40 /58(68.97%) patients. Cogan twitch was observed in 28/58(48.28%)
patients. Sensitivity of Rest test was 50%. Sensitivity of Ice test was 72.4%. Ice test positivity was 90%
(9/10) in mild, 75% (21/28) in moderate, 68.75% (11/16) in severe ptosis indicating that increasing severity
decreases the sensitivity. Sensitivity of combined Rest test and ice test was 90 %. Sensitivity of RNS study
was 90%. The difference between the RNS study and Ice test was not statistically significant (p- 0.583).
However RNS study showed higher percentage of positivity.
Conclusion: Ice test is more sensitive than rest test. Rest test and Ice test are simple, cost benefit bed side
tests when combined, have sensitivity equivalent to RNS study. However RNS study is the gold standard
confirmatory test.

Keywords: Cogan Twitch, Ice Test, Myasthenia, Rest Test.

Doi : 10.18231/j.ijceo.2020.017

How to cite : Lavanya S R, Padmavathy, Ramakrishnan, Office investigations for myasthenia gravis: comparative analysis. Indian J Clin Exp Ophthalmol 2020;6(1):74-79

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