COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details. editor@innovativepublication.com, rakesh.its@gmail.com, Mob. 8826373757, 8826859373, 9910947804


Print ISSN:-2395-1443

Online ISSN:-2395-1451

CODEN : IJCEKF

Current Issue

Year 2020

Volume: 6 , Issue: 1

Article Access statistics

Viewed: 951

Emailed: 0

PDF Downloaded: 203

Indian Journal of Clinical and Experimental Ophthalmology


Cross sectional case control study to establish the thickness of ganglion cell-inner plexiform (GC-IPL) layer thickness in type 2 diabetis (Type 2 DM) patients with diabetic retinopathy (DR) and compa


Full Text PDF Share on Facebook Share on Twitter


Author Details : Gopal S. Pillai, Manoj Prathapan

Volume : 3, Issue : 3, Year : 2017

Article Page : 306-309


Suggest article by email


Abstract

Aim: Primary Objective: To evaluate the macular GC-IPL layer thickness in Type 2 DM patients with diabetic retinopathy(DR) and compare its thickness with normal eyes.
Secondary Objective: To identify any possible relationship between the GC-IPL thickness and grade of DR, duration of detected DM, age and gender of the patient.
Materials and Methods: Patients were recruited from the outpatient clinic of the Department of Ophthalmology at Amrita Institute of Medical Sciences, Kochi, Kerala, India
Inclusion criteria
1.        Type 2 Diabetes with Mild Non Proliferative Diabetic Retinopathy (Mild NPDR) and Early Proliferative Diabetic Retinopath (Early PDR) without traction or vitreous hemorrhage (ETDRS classification)
2.        Early proliferative diabetic retinopathy(PDR) was defined as presence of either neovascularisation of disc /elsewhere or preretinal hemorrhages or both (ETDRS)
3.        Controls: Age-gender matched subjects free of ocular disease, diabetes, hypertension or other systemic diseases were recruited as controls from those who accompanied patients visiting the out patient clinic Statistically significant reduction of thickness of GC-IPL layer thickness between patients mild DR when compared to age matched controls (p=0.006).
Results
1.        Statistically significant reduction of GC-IPL thickness was seen in early PDR compared to controls (p<0.001).
2.        GC-IPL layer were thinner in patients with mild NPDR when compared to age matched controls.
3.        Difference in thickness between GC-IPL thickness between mild NPDR and early PDR was not statistically significant.
4.        There was no relationship between GC-IPL thickness and duration of detected DM, age and gender of the patient.
Conclusion
1.        There was a statistically significant reduction of thickness of GC-IPL layer thickness between mild NPDR and Early PDR when compared to age matched controls.  There was no significant difference between GC- IPL thickness between mild NPDR and early PDR.
2.        These results support the concept that diabetes has an early neurodegenerative effect on the retina which occurs even before the vascular component of DR occurs.
This reduction of GC-IPL thickness changes do not cause vision loss, but only supports neurodegenerative theory.

How to cite : Pillai G S, Prathapan M, Cross sectional case control study to establish the thickness of ganglion cell-inner plexiform (GC-IPL) layer thickness in type 2 diabetis (Type 2 DM) patients with diabetic retinopathy (DR) and compa. Indian J Clin Exp Ophthalmol 2017;3(3):306-309

Copyright © 2017 by author(s) and Indian J Clin Exp Ophthalmol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)