COVID-19 Update - This is to inform you that the Government of India has announced a complete lockdown in India 22nd March 2020 to 3rd May 2020. As a result, our offices will now be closed till 3rd May 2020 and all our employees will be working from home. Office telephones will not be answered, and therefore you are requested to direct all your queries related to manuscript submission, review process, publication etc. at below mentioned details.,, Mob. 8826373757, 8826859373, 9910947804

Print ISSN:-2395-1443

Online ISSN:-2395-1451


Current Issue

Year 2020

Volume: 6 , Issue: 1

Article Access statistics

Viewed: 701

Emailed: 0

PDF Downloaded: 302

Indian Journal of Clinical and Experimental Ophthalmology

A comparative study of rebamipide 2% and carboxy methylcellulose (CMC) 0.5% eye drop in patients with dry eyes: A randomized, hospital-based study

Full Text PDF Share on Facebook Share on Twitter

Author Details : Dipak B. Patel, Palvee Menon*, Anshi Rathod, Aneesha Vyas, Poonam Rana

Volume : 4, Issue : 4, Year : 2018

Article Page : 526-529

Suggest article by email


Aim: To compare the efficacy of 2% rebamipide and 0.5% Carboxy methylcellulose (CMC) eye drops in dry eye patients.
Materials and Methods: A 100 dry eye patients were enlisted and screened. Patients were allotted randomly into 2 groups-(Group-A) 2% rebamipide or (Group-B) 0.5% Carboxy methylcellulose (CMC) ophthalmic solution, after screening and instilled as 1 drop in each eye four times a day, for about two months. The signs and symptoms were assessed -at baseline, 2, 4, and at 8-week visits. The objective signs were –“Schirmer test and Tear film break-up time” (TBUT) while subjective symptoms were dry eye related ocular symptoms (foreign body sensation, dryness, photophobia, eye pain, and blurred vision.
Results: A compelling improvement was noticed in the Schirmer test and TBUT values after the treatment in the 2% rebamipide group. The patients on 2% rebamipide eye drop showed considerable improvement in dry eye related ocular symptoms, than the patients on 0.5% CMC eye drop (51% and 29% respectively) at 2 months.
Conclusions: 2% rebamipide ophthalmic solution was more efficient in improving both the subjective symptoms and objective signs of dry eye in comparison to the CMC group in this 8-week study. These findings showed that 2% rebamipide is the more effective drug for dry eye.

Keywords: Carboxy methylcellulose, Dry eye, Efficacy, Rebamipide.

Doi : 10.18231/2395-1451.2018.0118

How to cite : Patel D B, Menon P, Rathod A, Vyas A, Rana P, A comparative study of rebamipide 2% and carboxy methylcellulose (CMC) 0.5% eye drop in patients with dry eyes: A randomized, hospital-based study. Indian J Clin Exp Ophthalmol 2018;4(4):526-529

Copyright © 2018 by author(s) and Indian J Clin Exp Ophthalmol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (