Indian Journal of Clinical and Experimental Ophthalmology

Central corneal thickness: Correlation with intraocular pressure and disease severity in primary open angle glaucoma

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Author Details: Bindu S, Jyothi P.T, Aswathy.P

Volume : 2

Issue : 4

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 290

Article End Page : 294


Aim: To evaluate the relation between central corneal thickness (CCT), intraocular pressure (IOP) and vertical cup-disc ratio in Primary open angle glaucoma (POAG) compared to normal and to find out correlation between Central corneal thickness and disease severity in POAG.
Materials and Methods: Cross sectional study. Hundred patients on treatment for POAG and hundred age matched subjects were studied. Central corneal thickness was measured using ultrasound pachymeter. Intraocular pressure was measured by applanation tonometry. Statistical analysis was done using SPSS version 18.
Results: The mean CCT   in glaucoma patients was 528.03±33.37 μm in right eye and 529.69±34. 14 µm in the left eye. The mean value obtained for the control group was 541.46±31.20µm in right eye and 541.25±30.32 in left eye. There was no statistical significance in mean CCT values in males and females. CCT was found to decrease with age in both groups.  In glaucoma patients there was a positive correlation of CCT with IOP, and a negative correlation with vertical cup-disc ratio (VCDR). Patients with severe glaucoma had thinner cornea.
Conclusion: The average CCT obtained for normal as well as glaucoma patients in our study was lower than the suggested value of 555µm as a risk factor for development of glaucoma by Ocular hypertension study group. Patients with severe glaucoma had thinner cornea.  Hence our population maybe at a greater risk of developing glaucoma. In patients with POAG, CCT helps to identify patients with thinner cornea who may be at a higher risk of progression, and require more aggressive control.

Keywords: Central corneal thickness, Intraocular pressure, POAG- disease severity

Doi No:-10.18231