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IP Indian Journal of Immunology and Respiratory Medicine

Comparison of induced sputum and bronchial washings for CBNAAT in diagnosing sputum smear negative pulmonary tuberculosis

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Research Article

Author Details : Chilamakuru Raghavendra, G Ram Kumar Gupta*, V Venkata Ramana Reddy

Volume : 4, Issue : 4, Year : 2019

Article Page : 234-238

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Introduction: Tuberculosis is one of the most infectious public health problems for decades and has also
become difficult to diagnose in recent times due to association with immunocompromised status. With the
advent of the newer diagnostic technique like CBNAAT, can providing positive results even in less number
of tuberculos bacilli in specimen samples. The present study was aimed to compare induced sputum and
bronchial washings for CBNAAT in diagnosing sputum smear negative tuberculosis.
Materials and Methods: A prospective, observational study was conducted in the Department of
Pulmonary Medicine, Maharaja Institute of Medical Sciences (MIMS), Vizianagaram, Andhra Pradesh,
India. A total of 43 patients with sputum negative tuberculosis were enrolled and induced sputum and BAL
fluid for CBNAAT sent for analysis under RNTCP in district hospital.
Results: Male patients (67.45%) were more compared to the females (32.55%). Majority belongs to 51-60
years with mean age group of 49.18 years. Most common X- ray presentation was infiltration followed by
consolidation. Induced sputum CBNAAT was positive in only 07 patients compare d to bronchial washings
CBNAAT in 27 patients.
Conclusions: As CBNAAT can diagnose rapidly and prevent transmission and mortality in smearnegative
in pulmonary tuberculosis patients, all smear-negative and immunocompromised patients should
be subjected to CBNAAT. CBNAAT detects pulmonary TB in PLHIV with greater efficacy than sputum
microscopy, also helping in early diagnosis in less than 2 hours, so that early therapy can be started, thus
decreasing the incidence of MDR-TB and associated its mortality.

Keywords: Bronchial washings, CBNAAT, Induced sputum, Pulmonary tuberculosis, Smear negative.

Doi : 10.18231/j.ijirm.2019.054

How to cite : Raghavendra C, Gupta G R K, Reddy V V R, Comparison of induced sputum and bronchial washings for CBNAAT in diagnosing sputum smear negative pulmonary tuberculosis. IP Indian J Immunol Respir Med 2019;4(4):234-238

Copyright © 2019 by author(s) and IP Indian J Immunol Respir Med. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (