Article Access statistics

Viewed: 287

Emailed: 0

PDF Downloaded: 138

IP Indian Journal of Immunology and Respiratory Medicine


Burden of smoking on the pulmonary diffusing capacity in asymptomatic smokers with chronic kidney disease in comparison to non-smokers with chronic kidney disease


Full Text PDF Share on Facebook Share on Twitter


Research Article

Author Details : Prasanna Purna K, K Kalyani*, M Manoj Kumar, K Sai Sindhu, K Venkata Manohar

Volume : 4, Issue : 3, Year : 2019

Article Page : 150-153


Suggest article by email

Abstract

Background: The study was aimed to assess the additional risk of smoking as a risk factor on lung function and gaseous exchange by measuring diffusion capacity of lung for carbon monoxide (DLCO or TLCO) in chronic kidney disease patients (CKD) on hemodialysis.
Methodology: This was a cross-sectional observational study among smokers and non-smokers with chronic kidney disease who were clinically stable in the last four weeks, without a past history of pulmonary and cardiac disorders. Spirometry and DLCO tests were performed within 24 hours after hemodialysis.
Results: There were 40 CKD subjects on hemodialysis included in the study and were categorized into two groups as smokers & non-smokers. Smokers which included current smokers and forever smokers. All were males with the median age of 49.47 years and mean body mass index of 22.85 ± 2.29 kg/m2 and with a mean hemoglobin level of 9.59 ± 1.58 g/dl among Non-smokers and 8.63 ± 1.51 g/dl among smokers. The mean of DLCO among non-smokers with CKD was 49.35% of LLN of the normal value of DLCO which is mild to moderate degree of reduction and 25.48% among smokers with CKD which is of a severe degree of reduction. There was a significant relation between DLCO reduction with smoking history and also with CKD with a p-value of <0>
Conclusion: Reduction of diffusion capacity of the lung is common in chronic kidney disease patients even though not symptomatic. Risk factors for DLCO reduction like smoking further increase the disease burden adding to further morbidity with more decrease in DLCO.

Keywords: Carbon monoxide diffusing capacity; Chronic kidney disease; Smokers; Non-smokers.

Doi : 10.18231/j.ijirm.2019.034

How to cite : Prasanna Purna K, Kalyani K, Kumar M M, Sindhu K S, Manohar K V, Burden of smoking on the pulmonary diffusing capacity in asymptomatic smokers with chronic kidney disease in comparison to non-smokers with chronic kidney disease. IP Indian J Immunol Respir Med 2019;4(3):150-153

Copyright © 2019 by author(s) and IP Indian J Immunol Respir Med. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)